ArticleJournal of bacteriology2009
Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Periplasmic β-glucosidase BglX fromInternational journal of biochemistry and molecular biology · 2023Article
- Persistence and plasticity in bacterial gene regulation.Nature methods · 2021Article
- Quantifying the regulatory role of individual transcription factors in Escherichia coli.Cell reports · 2021Article
- Explainability in transformer models for functional genomics.Briefings in bioinformatics · 2021Article
- Identification and prevalence of in vivo-induced genes in enterohaemorrhagic Escherichia coli.Virulence · 2019Article
- A unified resource for transcriptional regulation in Escherichia coli K-12 incorporating high-throughput-generated binding data into RegulonDB version 10.0.BMC biology · 2018Article
- Transcription profile of Escherichia coli: genomic SELEX search for regulatory targets of transcription factors.Nucleic acids research · 2016Article
- Article
- Isobutanol production from cellobionic acid in Escherichia coli.Microbial cell factories · 2015Article
- Identification of the set of genes, including nonannotated morA, under the direct control of ModE in Escherichia coli.Journal of bacteriology · 2013Article
- Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.Nucleic acids research · 2012Article
- Multiple factors dictate target selection by Hfq-binding small RNAs.The EMBO journal · 2012Article
- Prokaryotic genome regulation: a revolutionary paradigm.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- Indirect repression by Bacillus subtilis CodY via displacement of the activator of the proline utilization operon.Journal of molecular biology · 2011Article
- Functionally important positions can comprise the majority of a protein's architecture.Proteins · 2011Article
- A novel nucleoid protein of Escherichia coli induced under anaerobiotic growth conditions.Nucleic acids research · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The asc operon of Escherichia coli is one of the cryptic genetic systems for beta-D-galactoside utilization as a carbon source. The ascFB genes for beta-D-galactoside transport and catabolism are repressed by the AscG regulator. After genomic SELEX screening, AscG was found to recognize and bind the consensus palindromic sequence TGAAACC-GGTTTCA. AscG binding was detected at two sites upstream of the ascFB promoter and at three sites upstream of the prpBC operon for propionate catabolism. In an ascG-disrupted mutant, transcription of ascFB was enhanced, in agreement with the repressor model of AscG. This repression was indicated to be due to interference of binding of cyclic AMP-CRP to the CRP box, which overlaps with the AscG-binding site 1, as well as binding of RNA polymerase to the promoter. Under conditions of steady-state E. coli growth in a rich medium, the intracellular level of AscG stayed constant at a level supposedly leading to tight repression of the ascFB operon. The level of prpR, encoding the activator of prpBCDE, was also increased in the absence of AscG, indicating the involvement of AscG in repression of prpR. Taken together, these data suggest a metabolic link through interplay between the asc and prp operons.
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