Evidence map›Paper›PMID 19632865›Full record

SynthesisAcademic radiology2009

Evaluating the correlation between film mammography and MRI for screening women with increased breast cancer risk.

Janie M Lee, Elkan F Halpern, Elizabeth A Rafferty, G Scott Gazelle

Abstract readComparative StudyEvaluation StudyMeta-Analysis
In one paragraph

Synthesis in Academic radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Breast imaging: A survey.World journal of clinical oncology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Janie M LeeDepartment of Radiology, Massachusetts General Hospital, Institute for Technology Assessment, 101 Merrimac Street, 10(th) Floor, Boston, MA 02114, USA. jlee45@partners.org
Elkan F Halpern
Elizabeth A Rafferty
G Scott Gazelle
Center for Assessment · USHarvard University · USMass General Brigham · US

Funding

Clinical and Economic Evaluation of Breast MRI for High-Risk ScreeningK07CA128816 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JANIE M · 2008 to 2012
$713k
NCI NIH HHS 1K07CA128816NCI NIH HHS K07 CA128816
6 · The paper itself

Abstract

RATIONALE AND

objectivesBreast magnetic resonance imaging (MRI) is increasingly being added to mammography for screening asymptomatic women at increased risk of breast cancer. Because the direction and extent of correlation between mammography and MRI could potentially result in over- or underestimation of the diagnostic gain related to using MRI as an adjunct to mammographic screening, we performed an analysis to evaluate the extent of correlation between mammography and MRI. MATERIALS AND

methodsWe reviewed the published literature to identify multimodality breast cancer screening studies reporting the sensitivity of mammography and MRI, alone and in combination, for breast cancer diagnosis. After calculating the expected sensitivity of combined mammography and MRI under conditions of test independence (no correlation), we compared the calculated and observed sensitivities for combined mammography and MRI. We then calculated correlation coefficients for mammography and MRI.

resultsSeven studies of multimodality screening in women at increased risk of developing breast cancer were included for analysis. Of these studies, the correlation between film mammography and MRI was positive in three studies, negative in two studies, and not identified in two studies. The calculated correlation coefficients ranged from -0.38 to 0.18. In six of seven studies, the 95% confidence interval for the correlation coefficient included 0.0, indicating no significant correlation.

conclusionsEvidence from published trials of multimodality breast cancer screening identified no statistically significant correlation between film mammography and MRI. Using both tests for breast cancer screening is likely to improve the early detection of breast cancer in women at increased risk.

Indexed as

Breast NeoplasmsFemaleHumansMagnetic Resonance ImagingMammographyMass ScreeningPrevalenceReproducibility of ResultsSensitivity and SpecificityStatistics as TopicX-Ray Film

Identifiers

PMID19632865
PMCPMC2763935
OpenAlexW1993867928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.