ArticleAtherosclerosis2010
A comprehensive histopathological evaluation of vascular medial fibrosis: insights into the pathophysiology of arterial stiffening.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- The Senescent Heart-"Age Doth Wither Its Infinite Variety".International journal of molecular sciences · 2024Review
- An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed.Frontiers in cardiovascular medicine · 2023Review
- Vein morphometry in end-stage kidney disease: Teasing out the contribution of age, comorbidities, and vintage to chronic wall remodeling.Frontiers in cardiovascular medicine · 2022Article
- Feasibility of longitudinal monitoring of atherosclerosis with pulse wave imaging in a swine model.Physiological measurement · 2021Article
- N-acetyl cysteine ameliorates aortic fibrosis by promoting M2 macrophage polarization in aging mice.Redox report : communications in free radical research · 2021Article
- Insulin Resistance is Associated with Subclinical Vascular Injury in Patients with a Kidney Disease.Current cardiology reviews · 2021Article
- Assessment of Myocardial Dysfunction by Three-Dimensional Echocardiography Combined With Myocardial Contrast Echocardiography in Type 2 Diabetes Mellitus.Frontiers in cardiovascular medicine · 2021Article
- Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing.Protein & cell · 2020Article
- Vitamin D Attenuates Loss of Endothelial Biomarker Expression in Cardio-Endothelial Cells.International journal of molecular sciences · 2020Article
- Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates.PloS one · 2019Article
- Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease.The journal of vascular access · 2019Article
- Histomorphometric analysis of the human internal thoracic artery and relationship with cardiovascular risk factors.PloS one · 2019Article
- Pathological Changes in Microvascular Morphology, Density, Size and Responses Following Comorbid Cerebral Injury.Frontiers in aging neuroscience · 2019Article
- Article
- Wnt-β Catenin Signaling Pathway: A Major Player in the Injury Induced Fibrosis and Dysfunction of the External Anal Sphincter.Scientific reports · 2017Article
- Aortic Arch Calcification as a Predictor of Repeated Arteriovenous Fistula Failure within 1-Year in Hemodialysis Patients.BioMed research international · 2017Article
- Preoperative graft assessment in aortocoronary bypass surgery.Experimental and therapeutic medicine · 2016Article
- Aortic Arch Calcification Predicts Patency Loss of Arteriovenous Fistula in End-Stage Renal Disease Patients.Scientific reports · 2016Article
- Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment.Current hypertension reports · 2016Article
- Noninvasive Imaging of Flow and Vascular Function in Disease of the Aorta.JACC. Cardiovascular imaging · 2015Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMedial vascular fibrosis contributes to arterial stiffening and reduced compliance, increasing the risk of cardiovascular events. We undertook the first comprehensive histopathologic study of medium-to-large caliber blood vessels (carotid, coronary, dorsalis pedis, internal mammary, iliac, mesenteric, pulmonary, and renal arteries) in 100 autopsy subjects to characterize medial fibrosis in relation to cardiovascular risk factors. METHODS AND
resultsMasson Trichrome staining of vascular tissue microarrays (TMAs) was digitally analyzed to determine the percent fibrosis (% collagen) of over 700 vascular segments. The percent fibrosis of the tunica media was strongly correlated within subjects across all systemic blood vessels (average r=0.53), suggesting that fibrosis is a global process independent of the predilection of the vessel towards the development of atherosclerosis. Hypertension, diabetes, age and poor renal function were significantly associated with increased systemic vascular fibrosis (p< or =0.03). By multivariable analysis, only poor renal function (p=0.003) was an independent predictor of higher levels of fibrosis. Finally, in a subset of 13 individuals we observed a significant correlation between pre-mortem pulse pressure and systemic vascular fibrosis (p<0.001).
conclusionsThis study demonstrates that vascular fibrosis is a global process associated with diseases of aging and elevated pulse pressures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.