ArticleDevelopmental biology2009
A gain of function mutation causing skeletal overgrowth in the rapunzel mutant.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- GRAMMAR-Lambda Delivers Efficient Understanding of the Genetic Basis for Head Size in Catfish.Biology · 2025Article
- Mutation ofGenes · 2022Article
- Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish.Genetics · 2020Article
- Construction of a high-density genetic map and mapping of growth related QTLs in the grass carp (Ctenopharyngodon idellus).BMC genomics · 2020Article
- Zebrafish RPZ5 Degrades Phosphorylated IRF7 To Repress Interferon Production.Journal of virology · 2019Article
- Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds.Frontiers in endocrinology · 2019Review
- The MetalloproteinaseFrontiers in neural circuits · 2019Article
- Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin.Scientific reports · 2018Article
- A gene expression study of ornamental fin shape in Neolamprologus brichardi, an African cichlid species.Scientific reports · 2017Article
- The Lungfish Transcriptome: A Glimpse into Molecular Evolution Events at the Transition from Water to Land.Scientific reports · 2016Article
- Keeping at arm's length during regeneration.Developmental cell · 2014Review
- Novel role for carbamoyl phosphate synthetase 2 in cranial sensory circuit formation.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- Bioelectric signaling regulates size in zebrafish fins.PLoS genetics · 2014Article
- Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.Journal of leukocyte biology · 2013Article
- Dermoskeleton morphogenesis in zebrafish fins.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mechanisms that regulate the growth and form of the vertebrate skeleton are largely unknown. The zebrafish mutant rapunzel has heterozygous defects in bone development, resulting in skeletal overgrowth, thus identification of the genetic lesion underlying rapunzel might provide insight into the molecular basis of skeletogenesis. In this report, we demonstrate that the rapunzel mutant results from a missense mutation in the previously uncharacterized rpz gene. This conclusion is supported by genetic mapping, identification of a missense mutation in rapunzel(c14) in a highly conserved region of the rpz gene, and suppression of the rapunzel homozygous embryonic phenotype with morpholino knockdown of rpz. In addition, rpz transcripts are identified in regions correlating with the homozygous embryonic phenotype (head, pectoral fin buds, somites and fin fold). This report provides the first gene identification for a mutation affecting segment number in the zebrafish fin and development of both the fin ray (dermal) and the axial skeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.