Trial reportInternational journal of radiation oncology, biology, physics2010
Functional interference clusters in cancer patients with bone metastases: a secondary analysis of RTOG 9714.
Trial report in International journal of radiation oncology, biology, physics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00003162 (Randomized Trial of Palliative Radiation Therapy for Osseous Metastases), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial of Palliative Radiation Therapy for Osseous Metastases: A Study of Palliation of Symptoms and Quality of Life
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Factors Affecting the Quality of Life of Patients with Painful Spinal Bone Metastases.Healthcare (Basel, Switzerland) · 2021Article
- A randomized trial of conventional fraction versus hypofraction radiotherapy for bone metastases from hepatocellular carcinoma.Journal of Cancer · 2019Article
- Evaluation of Quality of Life Using EORTC QLQ-BM22 in Patients with Bone Metastases after Treatment with Magnetic Resonance Guided Focused Ultrasound.Orthopaedic surgery · 2018Article
- Quality of life after palliative radiotherapy in bone metastases: A literature review.Journal of bone oncology · 2015Review
- Functional impairments as symptoms in the symptom cluster analysis of patients newly diagnosed with advanced cancer.Journal of pain and symptom management · 2013Article
- Confirmatory factor analysis of brief pain inventory (BPI) functional interference clusters in patients with bone metastases.Journal of pain management · 2010Article
- Comparison of single versus multiple fractions for palliative treatment of painful bone metastasis: first study from north west India.Indian journal of palliative careArticle
- Utilization Patterns of Single-Fraction and Short-Course Radiotherapeutic Schedules in the Management of Bone Metastases.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 2 countries.
Funding
Abstract
purposeTo explore the relationships (clusters) among the functional interference items in the Brief Pain Inventory (BPI) in patients with bone metastases.
methodsPatients enrolled in the Radiation Therapy Oncology Group (RTOG) 9714 bone metastases study were eligible. Patients were assessed at baseline and 4, 8, and 12 weeks after randomization for the palliative radiotherapy with the BPI, which consists of seven functional items: general activity, mood, walking ability, normal work, relations with others, sleep, and enjoyment of life. Principal component analysis with varimax rotation was used to determine the clusters between the functional items at baseline and the follow-up. Cronbach's alpha was used to determine the consistency and reliability of each cluster at baseline and follow-up.
resultsThere were 448 male and 461 female patients, with a median age of 67 years. There were two functional interference clusters at baseline, which accounted for 71% of the total variance. The first cluster (physical interference) included normal work and walking ability, which accounted for 58% of the total variance. The second cluster (psychosocial interference) included relations with others and sleep, which accounted for 13% of the total variance. The Cronbach's alpha statistics were 0.83 and 0.80, respectively. The functional clusters changed at week 12 in responders but persisted through week 12 in nonresponders.
conclusionPalliative radiotherapy is effective in reducing bone pain. Functional interference component clusters exist in patients treated for bone metastases. These clusters changed over time in this study, possibly attributable to treatment. Further research is needed to examine these effects.
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