ArticleAmerican journal of obstetrics and gynecology2009
Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study.
Article in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 276 citations in OpenAlex.
- Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.Cardiovascular diabetology · 2024Pooled it
- OLIDIAG Study: Extra Virgin Olive Oil Supplementation in the Diet of Women with Gestational Diabetes Mellitus-A Randomized Clinical Trial.Nutrients · 2026Trial
- Lipid and Glucose Profiles in Pregnant Women With HIV on Tenofovir-based Antiretroviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Trial
- Metabolic syndrome in obesity: treatment success and adverse pregnancy outcomes with ovulation induction in polycystic ovary syndrome.American journal of obstetrics and gynecology · 2021Trial
- High serum triglyceride levels in the early first trimester of pregnancy are associated with gestational diabetes mellitus: A prospective cohort study.Journal of diabetes investigation · 2020Trial
- Maternal plasma lipid levels across pregnancy and the risks of small-for-gestational age and low birth weight: a cohort study from rural Gambia.BMC pregnancy and childbirth · 2020Trial
- The Impact of a Cultural Lifestyle Intervention on Metabolic Parameters After Gestational Diabetes Mellitus A Randomized Controlled Trial.Maternal and child health journal · 2018Trial
- Maternal plasma cholesterol and duration of pregnancy: A prospective cohort study in Ghana.Maternal & child nutrition · 2017Trial
- First-trimester lipoprotein(a) and longitudinal renal biomarker trajectories preceding preeclampsia: a pilot cohort study.Archives of gynecology and obstetrics · 2026Article
- Pre-pregnancy obesity, gestational weight gain, and their relationship with maternal lipid levels at delivery across racial and ethnic populations.American journal of physiology. Heart and circulatory physiology · 2026Article
- Impact of a Postpartum Hypertension Clinic on Cardiovascular Screening After Hypertensive Disorder of Pregnancy.JACC. Advances · 2026Article
- Maternal Serum Lipid Levels in the Third Trimester and Associated Factors in Vietnam.Obstetrics and gynecology international · 2026Article
- The Effect of a Supervised Exercise Program Throughout Pregnancy on Longitudinal Lipid Profile Changes: A Randomized Clinical Trial.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Severe Hypertriglyceridemia in Pregnancy: Clinical Approach and Management Strategies.JCEM case reports · 2025Article
- Lipid Profile and Management of Dyslipidemias in Pregnancy.Journal of cardiovascular development and disease · 2025Review
- Early pregnancy triglycerides and blood pressure: a combined predictor for preeclampsia.BMC pregnancy and childbirth · 2025Article
- Standardising lipid testing and reporting in the United Kingdom; a joint statement by HEART UK and The Association for Laboratory Medicine.Annals of clinical biochemistry · 2025Review
- Article
- Role of Immune Cells in Mediating the Effect of Lipids on Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Unresolved alterations in bile acid composition and dyslipidemia in maternal and cord blood after UDCA treatment for intrahepatic cholestasis of pregnancy.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. STUDY
designLipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.
resultsLipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.
conclusionLipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.
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Registered trials
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