ArticleLife sciences2009
Effects of pyrrolidine dithiocarbamate on high-fat diet-induced metabolic and renal alterations in rats.
Article in Life sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Cholesterol-Lowering Effects of Asperidine B, a Pyrrolidine Derivative from the Soil-Derived FungusPharmaceuticals (Basel, Switzerland) · 2022Article
- Super-Resolution Ultrasound Imaging Provides Quantification of the Renal Cortical and Medullary Vasculature in Obese Zucker Rats: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- The Versatility in the Applications of Dithiocarbamates.International journal of molecular sciences · 2022Review
- Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.BMC nephrology · 2021Article
- Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats.Cardiovascular diabetology · 2015Article
- Pyrrolidine dithiocarbamate reduces the progression of total kidney volume and cyst enlargement in experimental polycystic kidney disease.Physiological reports · 2014Article
- Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy.PloS one · 2014Article
- Protective effects of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate in bladder ischemia-reperfusion injury in rats.Molecular biology reports · 2013Article
- Pyrrolidine dithiocarbamate enhances hepatic glycogen synthesis and reduces FoxO1-mediated gene transcription in type 2 diabetic rats.American journal of physiology. Endocrinology and metabolism · 2012Article
- Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats.Antioxidants & redox signaling · 2012Article
- ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation.Molecular and cellular biochemistry · 2012Article
- Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation.The Journal of pharmacology and experimental therapeutics · 2011Article
- A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress.PloS one · 2011Article
- Central adiposity, systemic inflammation, and the metabolic syndrome.Current hypertension reports · 2010Review
- NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes.Cardiovascular research · 2010Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
aimsWe investigated the effects of the nuclear factor kappa B (NFkappaB) blocker pyrrolidine dithiocarbamate (PDTC) on high-fat diet (HFD)-induced metabolic and renal alterations in obese and lean Zucker rats (OZR and LZR, respectively). MAIN
methodsRats were fed a HFD resembling the typical "Western" diet or a regular diet (RD) and allowed free access to tap water or tap water containing PDTC (150 mg/kg body weight) for 10 weeks; rats were then sacrificed. Total ROS production rates were measured using electron paramagnetic resonance spectroscopy, and superoxide production was measured with lucigenin assay. Blood, plasma, and urine were analyzed. Semi-quantitative reverse transcriptase-polymerase chain reaction and electrophoretic mobility shift assay were conducted to assess NFkappaB mRNA levels and DNA binding activities, respectively; immunofluorescence was performed to assess protein levels. KEY
findingsOZR-HFD rats exhibited significantly higher levels of total renal cortical reactive oxygen species production, plasma lipids, insulin, C-reactive protein, blood urea nitrogen, creatinine, and urinary albumin excretion than all other groups (p<0.05); these changes were accompanied by a significant decrease in plasma high density lipoprotein levels (p<0.05). Gene expression levels of desmin, cytokine and oxidative stress genes were significantly higher in the renal cortical tissues of OZR-HFD; NFkappaB p65 DNA binding activity was also significantly higher in these animals. PDTC attenuated these changes. SIGNIFICANCE: Our data suggest that NFkappaB blockade may prove beneficial in treating the nephropathy often associated with metabolic syndrome.
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Registered trials
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