ArticleDevelopmental biology2009
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 39 citations in OpenAlex.
- Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation.Signal transduction and targeted therapy · 2023Article
- Wnt signaling in lung development, regeneration, and disease progression.Communications biology · 2021Review
- WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis.American journal of respiratory and critical care medicine · 2019Article
- Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis.Development (Cambridge, England) · 2019Article
- Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.Development (Cambridge, England) · 2019Article
- Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways.FEBS letters · 2017Article
- Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift.Virchows Archiv : an international journal of pathology · 2017Article
- Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.Cell stem cell · 2017Article
- Article
- Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- β-catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Article
- Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm.Stem cells (Dayton, Ohio) · 2015Article
- Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Cognitive flexibility and long-term depression (LTD) are impaired following β-catenin stabilization in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.Developmental biology · 2013Article
- Gene expression signatures: a new approach to understanding the pathophysiology of chronic rhinosinusitis.Current allergy and asthma reports · 2013Review
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The precise mechanisms by which beta-catenin controls morphogenesis and cell differentiation remain largely unknown. Using embryonic lung development as a model, we deleted exon 3 of beta-catenin via Nkx2.1-cre in the Catnb[+/lox(ex3)] mice and studied its impact on epithelial morphogenesis. Robust selective accumulation of truncated, stabilized beta-catenin was found in Nkx2.1-cre;Catnb[+/lox(ex3)] lungs that were associated with the formation of polyp-like structures in the trachea and main-stem bronchi. Characterization of polyps suggests that accumulated beta-catenin impacts epithelial morphogenesis in at least two ways. "Intracellular" accumulation of beta-catenin blocked differentiation of spatially-appropriate airway epithelial cell types, Clara cells, ciliated cells and basal cells, and activated UCHL1, a marker for pulmonary neuroendocrine cells. There was also evidence for a "paracrine" impact of beta-catenin accumulation, potentially mediated via activation of Bmp4 that inhibited Clara and ciliated, but not basal cell differentiation. Thus, excess beta-catenin can alter cell fate determination by both direct and paracrine mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.