ArticleJournal of neuroimmunology2009
Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.
Article in Journal of neuroimmunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Increased VH4+JH6+ antibody heavy chain use in plasmablasts from asymptomatic multiple sclerosis patients.Genes and immunity · 2026Article
- Dynamic kernel matching for non-conforming data: A case study of T cell receptor datasets.PloS one · 2023Article
- Skewing of the antibody repertoire in cerebrospinal fluid B cells from healthy controls and patients with schizophrenia.Behavioural brain research · 2022Article
- Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications.Current neuropharmacology · 2022Review
- Next Generation Sequencing of Cerebrospinal Fluid B Cell Repertoires in Multiple Sclerosis and Other Neuro-Inflammatory Diseases-A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2021Review
- Comparison of Two Strategies to Generate Antigen-Specific Human Monoclonal Antibodies: Which Method to Choose for Which Purpose?Frontiers in immunology · 2021Article
- Ozanimod to Treat Relapsing Forms of Multiple Sclerosis: A Comprehensive Review of Disease, Drug Efficacy and Side Effects.Neurology international · 2020Review
- Single-Cell High-Throughput Technologies in Cerebrospinal Fluid Research and Diagnostics.Frontiers in immunology · 2019Review
- Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis.International journal of molecular sciences · 2017Article
- Statistical classifiers for diagnosing disease from immune repertoires: a case study using multiple sclerosis.BMC bioinformatics · 2017Article
- Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.Acta neuropathologica · 2017Article
- High-throughput sequencing of immune repertoires in multiple sclerosis.Annals of clinical and translational neurology · 2016Review
- Practical guidelines for B-cell receptor repertoire sequencing analysis.Genome medicine · 2015Review
- MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing.Gene · 2015Article
- The Ins and Outs of B Cells in Multiple Sclerosis.Frontiers in immunology · 2015Review
- Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future.Expert review of clinical immunology · 2015Review
- Intrathecal IgG synthesis: a resistant and valuable target for future multiple sclerosis treatments.Multiple sclerosis international · 2015Review
- B cells in MS and NMO: pathogenesis and therapy.Seminars in immunopathology · 2014Review
- The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.Frontiers in neurology · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.