ReviewCurrent drug abuse reviews2009
From QTL to candidate gene: a genetic approach to alcoholism research.
Review in Current drug abuse reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Flying Together:International journal of molecular sciences · 2020Review
- Interactions Between Alcohol and the Endocannabinoid System.Alcoholism, clinical and experimental research · 2020Review
- Estrogen-Dependent Upregulation ofFrontiers in genetics · 2018Article
- Gene expression profiling in the human alcoholic brain.Neuropharmacology · 2017Review
- A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.International review of neurobiology · 2016Review
- Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours.The international journal of neuropsychopharmacology · 2014Article
- Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains.Alcoholism, clinical and experimental research · 2014Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data.Physiological genomics · 2013Article
- A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.Synapse (New York, N.Y.) · 2013Article
- Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2.Alcohol (Fayetteville, N.Y.) · 2013Article
- Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks.In silico pharmacology · 2013Review
- Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.Pharmacology, biochemistry, and behavior · 2012Review
- Genome-wide expression analysis reveals diverse effects of acute nicotine exposure on neuronal function-related genes and pathways.Frontiers in psychiatry · 2011Article
- The complexity of alcohol drinking: studies in rodent genetic models.Behavior genetics · 2010Review
- DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics.Pharmacogenomics and personalized medicine · 2010Article
- Quantitative proteomics in laser capture microdissected sleep nuclei from rat brain.Journal of neurogeneticsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A major focus of research in alcohol-related disorders is to identify the genes and pathways that modulate alcohol-seeking behavior. In light of this, animal models have been established to study various aspects of alcohol dependence. The selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines were developed from Wistar rats to model high and low voluntary alcohol consumption, respectively. Using inbred P and NP strains, a strong QTL (LOD-9.2) for alcohol consumption was identified on rat chromosome 4. To search for candidate genes that underlie this chromosomal region, complementary molecular-based strategies were implemented to identify genetic targets that likely contribute to the linkage signal. In an attempt to validate these genetic targets, corroborative studies have been utilized including pharmacological studies, knock-out/transgenic models as well as human association studies. Thus far, three candidate genes, neuropeptide Y (Npy), alpha-synuclein (Snca), and corticotrophin-releasing factor receptor 2 (Crhr2), have been identified that may account for the linkage signal. With the recent advancements in bioinformatics and molecular biology, QTL analysis combined with molecular-based strategies provides a systematic approach to identify candidate genes that contribute to various aspects of addictive behavior.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.