ReviewAnnual review of medicine2009
The expanded biology of serotonin.
Review in Annual review of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 900 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
900 citing papers in PubMed, 3 syntheses or guidelines pooled it, 2,022 citations in OpenAlex.
- Effects of serotonergic pharmacological manipulation on exercise performance and central fatigue: a systematic review and three-level meta-analysis.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Role of 5-HTBiomolecules · 2025Pooled it
- The Association of Antidepressants in Late Pregnancy with Postpartum Hemorrhage: Systematic Review of Controlled Observational Studies.Journal of child and adolescent psychopharmacology · 2024Pooled it
- Long-term safety and effectiveness of fenfluramine in children and adults with Dravet syndrome.Epilepsia · 2025Trial
- Association between whole-grain consumption, tryptophan metabolism and psychological distress: a secondary analysis of a randomised controlled trial.The British journal of nutrition · 2024Trial
- Exploring the role of serotonin as a plant stress modulator.Plant signaling & behavior · 2026Review
- Methods for storage and determination of tryptophan and serotonin in bovine blood by high-performance liquid chromatography with fluorescence detection.Veterinary and animal science · 2026Article
- Simultaneous determination of serotonin and its precursor tryptophan in small volumes of human serum using HPLC-ECD.MethodsX · 2026Article
- Seconds-resolved in vivo measurements reveal rapid, serotonin transporter-independent plasma serotonin clearance.Blood vessels, thrombosis & hemostasis · 2026Article
- Canonical and Non-Canonical Regulators of Lipid Metabolism in the Liver and the "Liver-Other Organs" Axes.International journal of molecular sciences · 2026Review
- Deciphering the allosteric landscape of 5-HTPharmacological reports : PR · 2026Article
- Effects ofFoods (Basel, Switzerland) · 2026Article
- Unraveling the Mechanistic Insights ofNutrients · 2026Review
- The Association Between Peripheral Complete Blood Count Parameters and Depressive Symptoms: A Cross-Sectional Study in Eastern Sudan.Journal of clinical medicine · 2026Article
- Tryptophan metabolism in tumor microenvironment and therapeutic implications.Journal of advanced research · 2026Review
- A suite of engineered mice for interrogating psychedelic drug actions.Nature neuroscience · 2026Article
- Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study.Matrix biology plus · 2026Article
- Identification of novel serotonin transporter (SERT) inhibitors via large-scale machine learning-based virtual screening and molecular dynamics simulations.Molecular diversity · 2026Article
- Y-type molecular sieve framework for efficient enrichment of urinary serotonin prior to screening for type 2 diabetes by LC-MS/MS.Mikrochimica acta · 2026Article
- Alterations in Gut Microbiota and Serum Metabolome Are Associated with Postpartum Depression.Nutrients · 2026Article
840 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a wide range of neuropsychological processes, and drugs that target serotonin receptors are used widely in psychiatry and neurology. However, most serotonin is found outside the central nervous system, and virtually all of the 15 serotonin receptors are expressed outside as well as within the brain. Serotonin regulates numerous biological processes including cardiovascular function, bowel motility, ejaculatory latency, and bladder control. Additionally, new work suggests that serotonin may regulate some processes, including platelet aggregation, by receptor-independent, transglutaminase-dependent covalent linkage to cellular proteins. We review this new "expanded serotonin biology" and discuss how drugs targeting specific serotonin receptors are beginning to help treat a wide range of diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.