ArticleRadiation research2009
Radiation nephropathy is not mitigated by antagonists of oxidative stress.
Article in Radiation research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Radiation-induced kidney toxicity: molecular and cellular pathogenesis.Radiation oncology (London, England) · 2021Review
- Lack of Cellular Inflammation in a Non-human Primate Model of Radiation Nephropathy.Health physics · 2020Article
- Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance.Radiation research · 2019Article
- Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.PloS one · 2015Article
- Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.Antioxidants & redox signaling · 2014Review
- Chronic oxidative stress after irradiation: An unproven hypothesis.Medical hypotheses · 2013Review
- Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy.Journal of genetic disorders & genetic reports · 2013Article
- Salen Mn complexes mitigate radiation injury in normal tissues.Anti-cancer agents in medicinal chemistry · 2011Review
- Mitigation of radiation injuries via suppression of the renin-angiotensin system: emphasis on radiation nephropathy.Current drug targets · 2010Review
- Chronic kidney disease after hematopoietic stem cell transplantation.Seminars in nephrology · 2010Review
- Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?Current drug targets · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Abstract Persistent, chronic oxidative injury may play a mechanistic role in late radiation injury. Thus antioxidants may be useful as mitigators of radiation injury. The antioxidants deferiprone, genistein and apocynin were tested in a rat radiation nephropathy model that uses single-fraction total-body irradiation (TBI) followed by syngeneic bone marrow transplant. Deferiprone was added to the drinking water at 1.0 or 2.5 g/liter, starting 3 days after the TBI. Urinary bleomycin-detectable iron, which could enhance production of oxygen radicals, was reduced in the rats on deferiprone compared to untreated rats, but deferiprone did not mitigate radiation nephropathy. Genistein added to the chow at 750 mg/kg starting immediately after TBI did not mitigate radiation nephropathy. Apocynin added to the drinking water at 250 mg/liter immediately after TBI did not mitigate radiation nephropathy. Thus three different types of antioxidants, when used at doses consistent with an antioxidant effect, had no mitigation efficacy against radiation nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.