ArticleJournal of the American Chemical Society2009
A new gadolinium-based MRI zinc sensor.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 168 citations in OpenAlex.
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- Molecular MRI of Dysregulated Zinc Secretion Detects Pancreatic Ductal Adenocarcinoma and Response to KRASG12D Inhibitor Treatment.Cancer research · 2025Article
- Zn(II)-Responsive MRI Probe Based on an Fe(III) Macrocyclic Complex.Inorganic chemistry · 2024Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- A Reactive and Specific Sensor for Activity-BasedACS sensors · 2024Article
- Molecular Engineering of Self-Immolative Bioresponsive MR Probes.Journal of the American Chemical Society · 2023Article
- Rational design of a genetically encoded NMR zinc sensor.Chemical science · 2023Article
- Competitive Displacement Restores the HyperpolarizedACS physical chemistry Au · 2023Article
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.Inorganic chemistry · 2021Article
- Imaging Beta-Cell Function in the Pancreas of Non-Human Primates Using a Zinc-Sensitive MRI Contrast Agent.Frontiers in endocrinology · 2021Article
- From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Application of Nanomaterials in Biomedical Imaging and Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2020Review
- Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.Inorganic chemistry · 2020Review
- Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes.Journal of inorganic biochemistry · 2020Article
- Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.Dalton transactions (Cambridge, England : 2003) · 2020Article
- Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.Journal of the American Chemical Society · 2019Review
- Amino Acid-Derived Sensors for Specific ZnChemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the LiverJournal of the American Chemical Society · 2019Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The properties of a novel Gd(3+)-based MRI zinc sensor are reported. Unlike previously reported Gd(3+)-based MRI contrast agents, this agent (GdL) differs in that the agent alone binds only weakly with human serum albumin (HSA), while the 1:2 GdL:Zn(2+) ternary complex binds strongly to HSA resulting in a substantial, 3-fold increase in water proton relaxivity. The GdL complex is shown to have a relatively strong binding affinity for Zn(2+) (K(D) = 33.6 nM), similar to the affinity of the Zn(2+) ion with HSA alone. The agent detects as little as 30 microM Zn(2+) in the presence of HSA by MRI in vitro, a value slightly more than the total Zn(2+) concentration in blood (approximately 20 microM). This combination of binding affinity constants and the high relaxivity of the agent when bound to HSA suggests that this new agent may be useful for detection of free Zn(2+) ions in vivo without disrupting other important biological processes involving Zn(2+).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.