ArticleRapid communications in mass spectrometry : RCM2009
Dissociation of disulfide-intact somatostatin ions: the roles of ion type and dissociation method.
Article in Rapid communications in mass spectrometry : RCM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recent Developments in Gas-Phase Ion/Ion Reactions for Analytical Mass Spectrometry.Analytical chemistry · 2020Review
- Characterization of Protein Disulfide Linkages by MS In-Source Dissociation Comparing to CID and ETD Tandem MS.Journal of the American Society for Mass Spectrometry · 2019Article
- Novel Peptide Ion Chemistry Associated with Gold (I) Cationization: Preferential Cleavage at Lysine Residues.International journal of mass spectrometry · 2018Article
- Top-Down Charge Transfer Dissociation (CTD) of Gas-Phase Insulin: Evidence of a One-Step, Two-Electron Oxidation Mechanism.Journal of the American Society for Mass Spectrometry · 2018Article
- Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 3. Estimating Surface Area Exposure by Deuterium Uptake.Journal of the American Society for Mass Spectrometry · 2016Article
- Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry.Chemical science · 2015Article
- Enhancing the quality of H/D exchange measurements with mass spectrometry detection in disulfide-rich proteins using electron capture dissociation.Analytical chemistry · 2014Article
- Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries.Chemical communications (Cambridge, England) · 2013Article
- Does Electron Capture Dissociation Cleave Protein Disulfide Bonds?ChemistryOpen · 2012Article
- Dissociation Behavior of Tryptic and Intramolecular Disulfide-linked Peptide Ions Modified in the Gas Phase via Ion/Ion Reactions.International journal of mass spectrometry · 2012Article
- Electron transfer dissociation (ETD) of peptides containing intrachain disulfide bonds.Journal of the American Society for Mass Spectrometry · 2012Article
- Cleavage of Multiple Disulfide Bonds in Insulin via Gold Cationization and Collision-induced Dissociation.International journal of mass spectrometry · 2011Article
- Effectiveness of CID, HCD, and ETD with FT MS/MS for degradomic-peptidomic analysis: comparison of peptide identification methods.Journal of proteome research · 2011Article
- Gas-phase fragmentation of [M+nH+OH]n•+ ions formed from peptides containing intra-molecular disulfide bonds.Journal of the American Society for Mass Spectrometry · 2011Article
- Collision induced dissociation products of disulfide-bonded peptides: ions result from the cleavage of more than one bond.Journal of the American Society for Mass Spectrometry · 2011Article
- Ion/neutral, ion/electron, ion/photon, and ion/ion interactions in tandem mass spectrometry: do we need them all? Are they enough?Journal of the American Society for Mass Spectrometry · 2011Article
- Electron transfer dissociation coupled to an Orbitrap analyzer may promise a straightforward and accurate sequencing of disulfide-bridged cyclic peptides: a case study.Journal of mass spectrometry : JMS · 2010Article
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3 authors.
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Abstract
The dissociation chemistry of somatostatin-14 was examined using various tandem mass spectrometry techniques including low-energy beam-type and ion trap collision-induced dissociation (CID) of protonated and deprotonated forms of the peptide, CID of peptide-gold complexes, and electron transfer dissociation (ETD) of cations. Most of the sequence of somatostatin-14 is present within a loop defined by the disulfide linkage between Cys-3 and Cys-14. The generation of readily interpretable sequence-related ions from within the loop requires the cleavage of at least one of the bonds of the disulfide linkage and the cleavage of one polypeptide backbone bond. CID of the protonated forms of somatostatin did not appear to give rise to an appreciable degree of dissociation of the disulfide linkage. Sequential fragmentation via multiple alternative pathways tended to generate very complex spectra. CID of the anions proceeded through CH(2)-S cleavages extensively but relatively few structurally diagnostic ions were generated. The incorporation of Au(I) into the molecule via ion/ion reactions followed by CID gave rise to many structurally relevant dissociation products, particularly for the [M+Au+H](2+) species. The products were generated by a combination of S-S bond cleavage and amide bond cleavage. ETD of the [M+3H](3+) ion generated rich sequence information, as did CID of the electron transfer products that did not fragment directly upon electron transfer. The electron transfer results suggest that both the S-S bond and an N-C(alpha) bond can be cleaved following a single electron transfer reaction.
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