ArticleJournal of biomolecular NMR2009
Quantitative analysis of backbone motion in proteins using MAS solid-state NMR spectroscopy.
Article in Journal of biomolecular NMR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 83 citations in OpenAlex.
- Deuteration of proteins boosted by cell lysates: high-resolution amide and HMagnetic resonance (Gottingen, Germany) · 2024Article
- Accurate Determination of Motional Amplitudes in Biomolecules by Solid-State NMR.ACS physical chemistry Au · 2023Article
- Review
- Experimental Characterization of the Hepatitis B Virus Capsid Dynamics by Solid-State NMR.Frontiers in molecular biosciences · 2021Article
- Model-Free or Not?Frontiers in molecular biosciences · 2021Review
- Conformational Stability and Dynamics in Crystals Recapitulate Protein Behavior in Solution.Biophysical journal · 2020Article
- Determination of methyl order parameters using solid state NMR under off magic angle spinning.Journal of biomolecular NMR · 2019Article
- Localized and Collective Motions in HET-s(218-289) Fibrils from Combined NMR Relaxation and MD Simulation.Angewandte Chemie (International ed. in English) · 2019Article
- Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency.Journal of structural biology · 2019Article
- Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using ComplementaryJournal of the American Chemical Society · 2019Article
- Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.Nature communications · 2018Article
- Protein conformational dynamics studied bySolid state nuclear magnetic resonance · 2017Article
- Characterization of fibril dynamics on three timescales by solid-state NMR.Journal of biomolecular NMR · 2016Article
- Studying Dynamics by Magic-Angle Spinning Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules.Progress in nuclear magnetic resonance spectroscopy · 2016Review
- Magic angle spinning NMR of viruses.Progress in nuclear magnetic resonance spectroscopy · 2015Review
- Perspectives for sensitivity enhancement in proton-detected solid-state NMR of highly deuterated proteins by preserving water magnetization.Journal of biomolecular NMR · 2015Article
- Site-specific analysis of heteronuclear Overhauser effects in microcrystalline proteins.Journal of biomolecular NMR · 2014Article
- Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes.Journal of biomolecular NMR · 2014Article
- Amplitudes and time scales of picosecond-to-microsecond motion in proteins studied by solid-state NMR: a critical evaluation of experimental approaches and application to crystalline ubiquitin.Journal of biomolecular NMR · 2013Article
- Internal protein dynamics on ps to μs timescales as studied by multi-frequency (15)N solid-state NMR relaxation.Journal of biomolecular NMR · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a comprehensive analysis of protein dynamics for a micro-crystallin protein in the solid-state. Experimental data include (15)N T (1) relaxation times measured at two different magnetic fields as well as (1)H-(15)N dipole, (15)N CSA cross correlated relaxation rates which are sensitive to the spectral density function J(0) and are thus a measure of T (2) in the solid-state. In addition, global order parameters are included from a (1)H,(15)N dipolar recoupling experiment. The data are analyzed within the framework of the extended model-free Clore-Lipari-Szabo theory. We find slow motional correlation times in the range of 5 and 150 ns. Assuming a wobbling in a cone motion, the amplitude of motion of the respective amide moiety is on the order of 10 degrees for the half-opening angle of the cone in most of the cases. The experiments are demonstrated using a perdeuterated sample of the chicken alpha-spectrin SH3 domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.