Evidence map›Paper›PMID 19629689›Full record

SynthesisDigestive diseases and sciences2010

Mechanisms and potential applications of intestinal electrical stimulation.

Jieyun Yin, Jiande D Z Chen

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Enteric Neuromodulation for the Gut and Beyond.Cold Spring Harbor perspectives in medicine · 2020
    Review
  10. Use of Bioelectronics in the Gastrointestinal Tract.Cold Spring Harbor perspectives in medicine · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Changes of neuronal activities after gut electrical stimulation with different parameters and locations in lateral hypothalamus area of obese rats.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jieyun YinDivision of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, GI Research, Route 0655, Basic Science Building, Room 432, Galveston, TX 77555-0655, USA.
Jiande D Z Chen

Funding

Dual Pulse Electrical Stimulation for GastroparesisR44DK055437 · NIDDK · TRANSTIMULATION RESEARCH, INC. · PI CHEN, JIANDE · 2006 to 2007
$750k
THERAPEUTIC POTENTIAL OF INTESTINAL PACING FOR OBESITYR44DK063733 · NIDDK · TRANSTIMULATION RESEARCH, INC. · PI CHEN, JIANDE · 2006 to 2007
$649k
THERAPEUTIC POTENTIAL OF INTESTINAL PACING FOR OBESITYR43DK063733 · NIDDK · TRANSNEURONIX, INC. · PI CHEN, JIANDE · 2003 to 2003
$100k
Intestinal Pacing for Intestinal Pseudo-ObstructionR43DK075155 · NIDDK · TRANSTIMULATION RESEARCH, INC. · PI CHEN, JIANDE · 2007 to 2007
$100k
ELECTRICAL STIMULATION FOR TREATMENT OF GASTROPARESISR43DK055437 · NIDDK · LYNN HEALTH SCIENCE INSTITUTE · PI CHEN, JIANDE · 1999 to 1999
–
NIDDK NIH HHS DK055437NIDDK NIH HHS DK063733NIDDK NIH HHS DK075155
6 · The paper itself

Abstract

purposeElectrical stimulation of the gut has recently been under intensive investigation and various studies have revealed therapeutic potentials of gastrointestinal electrical stimulation for gastrointestinal motility disorders and obesity. While there have been a number of reviews on gastric electrical stimulation, there is a lack of systematic reviews on intestinal electrical stimulation. The aim of this review is to provide an overview on the effects, mechanisms, and applications of intestinal electrical stimulation.

resultsWe evaluated published data on intestinal electrophysiology, pathophysiology, and different methodologies on intestinal electrical stimulation and its possible mechanisms in both research and clinical settings using the MEDLINE database for English articles from 1963 to 2008. Based on this systematic review, intestinal electrical stimulation has been reported to alter intestinal slow waves, contractions and transit; the effects were mediated via both vagal and adrenergic pathways. Intestinal electrical stimulation has been reported to have potentials for treating various intestinal motility disorders and obesity.

conclusionsIt is concluded that intestinal electrical stimulation may have promising applications for treating motility disorders associated with altered intestinal contractile activity. The most recent studies have revealed possible applications of intestinal electrical stimulation for the treatment of obesity. Basic research results are promising; however, further clinical studies are needed to bring IES from bench to bedside.

Indexed as

Electric Stimulation TherapyAnimalsElectric StimulationGastrointestinal DiseasesGastrointestinal MotilityHumansIntestinesObesity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.