SynthesisJournal of assisted reproduction and genetics2009
IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis.
Synthesis in Journal of assisted reproduction and genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?Journal of assisted reproduction and genetics · 2023Pooled it
- PGT-A: who and when? Α systematic review and network meta-analysis of RCTs.Journal of assisted reproduction and genetics · 2021Pooled it
- Association between single euploid embryo transfer and pregnancy outcomes in women of advanced maternal age: a propensity score-matched analysis.Frontiers in endocrinology · 2026Article
- A decade of molecular preimplantation genetic diagnosis of 350 blastomeres for beta-thalassemia combined with HLA typing, aneuploidy screening and sex selection in Iran.BMC pregnancy and childbirth · 2022Article
- Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016-2018.Journal of assisted reproduction and genetics · 2021Article
- The Effect of Preimplantation Genetic Screening on Implantation Rate in Women over 35 Years of Age.Cell journal · 2016Article
- Metabolomic assessment of embryo viability.Seminars in reproductive medicine · 2014Review
- Preimplantation genetic screening: a practical guide.Clinical medicine insights. Reproductive health · 2013Article
- Follicular fluid protein content (FSH, LH, PG4, E2 and AMH) and polar body aneuploidy.Journal of assisted reproduction and genetics · 2012Article
- Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?Journal of assisted reproduction and genetics · 2011Review
- Preimplantation genetic diagnosis (PGD) for SHOX-related haploinsufficiency in conjunction with trisomy 21 detection by molecular analysis.Journal of assisted reproduction and genetics · 2011Article
- Singling out genetic disorders and disease.Genome medicine · 2010Article
- Comment on Checa MA et al. J Assist Reprod Genet DOI 10.1007/s10815-009-9328-4.Journal of assisted reproduction and genetics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.
methodsSystematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.
resultsTen randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.
conclusionsIn women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.