ArticleExtremophiles : life under extreme conditions2009
The Deinococcus radiodurans SMC protein is dispensable for cell viability yet plays a role in DNA folding.
Article in Extremophiles : life under extreme conditions, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis.Journal of cell science · 2025Article
- Surviving the storm: exploring the role of natural transformation in nutrition and DNA repair of stressedApplied and environmental microbiology · 2025Article
- Spatial chromosome organization and adaptation of the radiation-resistant extremophile Deinococcus radiodurans.The Journal of biological chemistry · 2025Article
- Characterization of the DdrD protein from the extremely radioresistant bacterium Deinococcus radiodurans.Extremophiles : life under extreme conditions · 2021Article
- Natural Transformation inFrontiers in microbiology · 2020Article
- Conservation and diversity of radiation and oxidative stress resistance mechanisms in Deinococcus species.FEMS microbiology reviews · 2019Review
- DdrI, a cAMP Receptor Protein Family Member, Acts as a Major Regulator for Adaptation of Deinococcus radiodurans to Various Stresses.Journal of bacteriology · 2018Article
- In vivo and in vitro characterization of DdrC, a DNA damage response protein in Deinococcus radiodurans bacterium.PloS one · 2017Article
- Deinococcus as new chassis for industrial biotechnology: biology, physiology and tools.Journal of applied microbiology · 2015Review
- Constitutive Stringent Response Restores Viability of Bacillus subtilis Lacking Structural Maintenance of Chromosome Protein.PloS one · 2015Article
- The bacterial chromosome: architecture and action of bacterial SMC and SMC-like complexes.FEMS microbiology reviews · 2014Review
- Interlinked sister chromosomes arise in the absence of condensin during fast replication in B. subtilis.Current biology : CB · 2014Article
- How to get (a)round: mechanisms controlling growth and division of coccoid bacteria.Nature reviews. Microbiology · 2013Review
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- Functional characterization of the role of the chromosome I partitioning system in genome segregation in Deinococcus radiodurans.Journal of bacteriology · 2012Article
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- Oxidative stress resistance in Deinococcus radiodurans.Microbiology and molecular biology reviews : MMBR · 2011Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deinococcus radiodurans contains a highly condensed nucleoid that remains to be unaltered following the exposure to high doses of gamma-irradiation. Proteins belonging to the structural maintenance of chromosome protein (SMC) family are present in all organisms and were shown to be involved in chromosome condensation, pairing, and/or segregation. Here, we have inactivated the smc gene in the radioresistant bacterium D. radiodurans, and, unexpectedly, found that smc null mutants showed no discernible phenotype except an increased sensitivity to gyrase inhibitors suggesting a role of SMC in DNA folding. A defect in the SMC-like SbcC protein exacerbated the sensitivity to gyrase inhibitors of cells devoid of SMC. We also showed that the D. radiodurans SMC protein forms discrete foci at the periphery of the nucleoid suggesting that SMC could locally condense DNA. The phenotype of smc null mutant leads us to speculate that other, not yet identified, proteins drive the compact organization of the D. radiodurans nucleoid.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.