ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 21 citations in OpenAlex.
- Genetic Dissection of Trabecular Bone Structure with Mouse Intersubspecific Consomic Strains.G3 (Bethesda, Md.) · 2017Article
- Two novel susceptibility loci for non-small cell lung cancer map to low-density lipoprotein receptor-related protein 5.Oncology letters · 2016Article
- Relationship between CATSPERB, NR5A2 gene polymorphisms and Peak Bone Mineral Density in College Students in China.Iranian journal of public health · 2014Article
- Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in postmenopausal women.Molecular biology reports · 2014Article
- Replication of Caucasian loci associated with bone mineral density in Koreans.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Article
- Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Genetics of osteoporosis: accelerating pace in gene identification and validation.Human genetics · 2010Review
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
unlabelledOsteoporosis is a major public health problem characterized by low bone mineral density (BMD). This replication study confirmed 38 single-nucleotide polymorphisms (SNPs) out of 139 SNPs previously reported in three recent genome-wide association studies (GWASs) in an independent US white sample. Ten SNPs achieved combined p < 3.6 x 10(-4).
introductionBMD is under strong genetic control. This study aims to verify the potential associations between BMD and candidate genes/loci reported by GWAS of FHS100K, Icelandic deCODE, and UK-NL.
methodsEight promising (at the genome-wide significant level after Bonferroni correction) and 131 available sub-promising (at the most stringent p value, p < 5.5 x 10(-5) in the three GWASs reports) SNPs were selected. By using genotypic information from Affymetrix 500 K SNP arrays, we tested their associations with BMD in 1,000 unrelated US whites. Fisher's combined probability method was used to quantify the overall evidence of association. BMD was measured by dual energy X-ray absorptiometry.
resultsTwo promising SNPs, rs3762397 and rs3736228, were replicated in the current study with p < 0.05. Besides, 36 sub-promising SNPs were replicated at the same significant level. Ten SNPs achieved significant combined p < 3.6 x 10(-4) (0.05/139 SNPs, corrected for multiple testing).
conclusionsOsteoporosis susceptibility of 38 SNPs was replicated in 1,000 unrelated US whites. This study showed promise for replication of some initial genome-wide association signals.
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