ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS).
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review.Nutrients · 2021Pooled it
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- Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Effectiveness of simple balancing training program in elderly patients with history of frequent falls.Clinical interventions in aging · 2011Trial
- Exploring the impact of vitamin D-related genetic variants on muscular fitness changes in middle-aged and older adults in Kosovo.Frontiers in public health · 2025Article
- Vitamin D supplementation and falls in residential aged care: A longitudinal multisite cohort study.Bone reports · 2024Article
- The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.EXCLI journal · 2019Article
- Vitamin D Status and Vitamin D Receptor Gene Polymorphisms Are Associated with Pelvic Floor Disorders in Women.Journal of menopausal medicine · 2018Article
- Osteosarcopenia: where bone, muscle, and fat collide.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Article
- Replication study of the vitamin D receptor (VDR) genotype association with skeletal muscle traits and sarcopenia.Aging clinical and experimental research · 2016Article
- Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case-control study.Journal of translational medicine · 2015Article
- Serum levels of 25-hydroxyvitamin D and functional outcome among postmenopausal women with hip fracture.PloS one · 2015Article
- Medication-induced osteoporosis: screening and treatment strategies.Therapeutic advances in musculoskeletal disease · 2014Review
- Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations.Aging and disease · 2014Review
- Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review.Journal of diabetes and metabolic disorders · 2014Article
- Anteroposterior displacement behavior of the center of pressure, without visual reference, in postmenopausal women with and without lumbar osteoporosis.Clinics (Sao Paulo, Brazil) · 2013Observational
- Genes and the ageing muscle: a review on genetic association studies.Age (Dordrecht, Netherlands) · 2013Review
- Vitamin D deficiency: subclinical and clinical consequences on musculoskeletal health.Current rheumatology reports · 2012Review
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Authors and funding
10 authors at 5 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryFall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.
introductionFall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.
methodsFalls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort--the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.
resultsCarriers of the 'B' allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.
conclusionsIn conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.
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