ArticleDeutsches Arzteblatt international2008
Polar body diagnosis - a step in the right direction?
Article in Deutsches Arzteblatt international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Polar Body Biopsy Helps in Reducing the Total Pregnancy Loss Rates in Intracytoplasmic Sperm Injection Cycles.Cureus · 2025Article
- The future of embryo engineering and fertility research in interdisciplinary collaboration.Frontiers in cell and developmental biology · 2025Review
- Aneuploidy detection in pooled polar bodies using rapid nanopore sequencing.Journal of assisted reproduction and genetics · 2024Article
- Chromosome Segregation in the Oocyte: What Goes Wrong during Aging.International journal of molecular sciences · 2022Review
- Live births after polar body biopsy and frozen-thawed cleavage stage embryo transfer: case report.JBRA assisted reproduction · 2016Article
- Preimplantation genetic screening: an effective testing for infertile and repeated miscarriage patients?Obstetrics and gynecology international · 2010Article
- Polar body biopsy in the diagnosis of monogenic diseases: the birth of three healthy children.Deutsches Arzteblatt international · 2009Article
- Preimplantation Genetic Testing for Breast Cancer.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPolar body diagnosis (PBD) is a new diagnostic method for the indirect genetic analysis of oocytes, which is carried out as part of in vitro fertilization. The biopsy of polar bodies is technically demanding and cannot be adopted uncritically in routine practice, in the absence of robust data to support this laboratory procedure.
methodsSelective literature review and analysis of own PBD data.
resultsThe main application of PBD is the detection of chromosomal aneuploidies and maternally inherited translocations in oocytes. The major disadvantage of PBD is that the paternal contribution to the genetic constitution of the developing embryo cannot be evaluated. Moreover, the potential value of polar body biopsy for the diagnosis of monogenetic diseases is limited. DISCUSSION: The role of PBD in improving of success rates in assisted reproduction requires evaluation in further clinical trials. For maternal translocations, PBD can be used to reduce the risk of miscarriage. Rapid development in the field of molecular diagnostic and biopsy techniques will also influence PBD and will most likely allow wider application of this method in the near future.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.