ArticleThe Journal of antibiotics2009
Synthesis and combinational antibacterial study of 5''-modified neomycin.
Article in The Journal of antibiotics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Pyrazolyl-functionalised Ag(i)-NHC complexes: synthesis, characterisation, antibacterial activity, and computational investigation.RSC advances · 2025Article
- An innovative strategy to treat pathogenic biofilm-associated infectionsRSC medicinal chemistry · 2025Article
- Conjugates of Aminoglycosides with Stapled Peptides as a Way to Target Antibiotic-Resistant Bacteria.ACS omega · 2023Article
- Tea Tree Oil Nanoemulsion-Based Hydrogel Vehicle for Enhancing Topical Delivery of Neomycin.Life (Basel, Switzerland) · 2022Article
- Amphiphilic aminoglycosides: Modifications that revive old natural product antibiotics.Frontiers in microbiology · 2022Review
- Alternatives to Fight Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals.Molecules (Basel, Switzerland) · 2018Article
- Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.Chemical Society reviews · 2018Review
- N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.ACS infectious diseases · 2017Article
- Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.Journal of medicinal chemistry · 2015Article
- New trends in aminoglycosides use.MedChemComm · 2014Article
- New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides.Antimicrobial agents and chemotherapy · 2014Article
- Antifungal Amphiphilic Aminoglycosides.MedChemComm · 2014Article
- Characterization of ribosomal binding and antibacterial activities using two orthogonal high-throughput screens.Antimicrobial agents and chemotherapy · 2013Article
- Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.Antimicrobial agents and chemotherapy · 2010Review
- A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides.MedChemCommArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A library of 5''-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed, which may lead to the development of novel therapeutic practices in the battle against infectious bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.