ReviewThe EMBO journal2009
Telomeres and disease.
Review in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 107 citations in OpenAlex.
- SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence.Experimental & molecular medicine · 2024Article
- Comparison of Telomere Length in Age-Matched Primiparous and Multiparous Brahman Cows.Animals : an open access journal from MDPI · 2023Article
- Nutrition Interventions of Herbal Compounds on Cellular Senescence.Oxidative medicine and cellular longevity · 2022Review
- Telomere Length Regulation.Frontiers in oncology · 2022Review
- Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts.Antioxidants (Basel, Switzerland) · 2021Article
- Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling.Cardiovascular research · 2021Article
- Three-Dimensional Nuclear Telomere Profiling as a Biomarker for Recurrence in Oligodendrogliomas: A Pilot Study.International journal of molecular sciences · 2020Article
- Telomere length varies substantially between blood cell types in a reptile.Royal Society open science · 2020Article
- Review
- Central nervous system myeloid cells as drug targets: current status and translational challenges.Nature reviews. Drug discovery · 2016Review
- Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics.Cellular and molecular life sciences : CMLS · 2015Review
- Forging a signature of in vivo senescence.Nature reviews. Cancer · 2015Review
- Telomere length in Chernobyl accident recovery workers in the late period after the disaster.Journal of radiation research · 2014Article
- Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.PLoS genetics · 2014Article
- The telomere profile distinguishes two classes of genetically distinct cutaneous squamous cell carcinomas.Oncogene · 2014Article
- Human RECQL1 participates in telomere maintenance.Nucleic acids research · 2014Article
- Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.Molecular and cellular biology · 2014Article
- 3D organization of telomeres in porcine neutrophils and analysis of LPS-activation effect.BMC cell biology · 2013Article
- Replication of telomeres and the regulation of telomerase.Cold Spring Harbor perspectives in biology · 2013Review
- Genetic susceptibility to lung cancer--light at the end of the tunnel?Carcinogenesis · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The telomeres of most eukaryotes are characterized by guanine-rich repeats synthesized by the reverse transcriptase telomerase. Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other diseases including cancer. Differences in telomerase deficiency phenotypes between species most likely reflect a tumour suppressor function of telomeres in long-lived mammals that does not exist as such in short-lived organisms. Another puzzle provided by current observations is that family members with the same genetic defect, haplo-insufficiency for one of the telomerase genes, can present with widely different diseases. Here, the crucial role of telomeres and telomerase in human (stem cell) biology is discussed from a Darwinian perspective. It is proposed that the variable phenotype and penetrance of heritable human telomerase deficiencies result from additional environmental, genetic and stochastic factors or combinations thereof.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.