ReviewThe EMBO journal2009
Taming the tiger by the tail: modulation of DNA damage responses by telomeres.
Review in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- A CDK-Dependent Phosphorylation of a Novel Domain of Rif1 Regulates its Function during Telomere Damage and Other Types of Stress.Molecular and cellular biology · 2023Article
- Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.Journal of cellular physiology · 2019Article
- Tpz1Communications biology · 2019Article
- Vps74 Connects the Golgi Apparatus and Telomeres inG3 (Bethesda, Md.) · 2018Article
- Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast.G3 (Bethesda, Md.) · 2017Article
- Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast.Cell cycle (Georgetown, Tex.) · 2016Article
- Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt.Nucleic acids research · 2016Article
- The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases.Journal of molecular biology · 2015Article
- Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins.PloS one · 2015Article
- Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres.PloS one · 2015Article
- Telomere regulation during the cell cycle in fission yeast.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Telomere-end processing: mechanisms and regulation.Chromosoma · 2013Article
- "Poisoning" yeast telomeres distinguishes between redundant telomere capping pathways.Chromosoma · 2012Article
- Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.PLoS genetics · 2012Article
- Similarities and differences between "uncapped" telomeres and DNA double-strand breaks.Chromosoma · 2012Review
- DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1.The EMBO journal · 2012Article
- DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression.Journal of oncology · 2012Article
- A novel checkpoint and RPA inhibitory pathway regulated by Rif1.PLoS genetics · 2011Article
- Telomere dysfunction, autoimmunity and aging.Aging and disease · 2011Article
- Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast.G3 (Bethesda, Md.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Telomeres are by definition stable and inert chromosome ends, whereas internal chromosome breaks are potent stimulators of the DNA damage response (DDR). Telomeres do not, as might be expected, exclude DDR proteins from chromosome ends but instead engage with many DDR proteins. However, the most powerful DDRs, those that might induce chromosome fusion or cell-cycle arrest, are inhibited at telomeres. In budding yeast, many DDR proteins that accumulate most rapidly at double strand breaks (DSBs), have important functions in physiological telomere maintenance, whereas DDR proteins that arrive later tend to have less important functions. Considerable diversity in telomere structure has evolved in different organisms and, perhaps reflecting this diversity, different DDR proteins seem to have distinct roles in telomere physiology in different organisms. Drawing principally on studies in simple model organisms such as budding yeast, in which many fundamental aspects of the DDR and telomere biology have been established; current views on how telomeres harness aspects of DDR pathways to maintain telomere stability and permit cell-cycle division are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.