ArticleInvestigative ophthalmology & visual science2010
Effects of elevated thyroid hormone on adult rabbit extraocular muscles.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.International journal of molecular sciences · 2024Review
- Carbonylation of atrial myosin prolongs its interaction with actin.European biophysics journal : EBJ · 2018Article
- Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.Investigative ophthalmology & visual science · 2015Article
- RNA expression analysis of passive transfer myasthenia supports extraocular muscle as a unique immunological environment.Investigative ophthalmology & visual science · 2014Article
- Postulating a role for connective tissue elements in inferior oblique muscle overaction (an American Ophthalmological Society thesis).Transactions of the American Ophthalmological Society · 2013Article
- Effects of recession versus tenotomy surgery without recession in adult rabbit extraocular muscle.Investigative ophthalmology & visual science · 2010Article
- Effects of hyperthyroidism on the rectus muscles in mice.Frontiers in neurology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeHuman extraocular muscles (EOM) are preferentially susceptible to thyroid eye disease. Although the specific cause of this autoimmune disorder is unknown, it is often associated with elevated thyroid hormone levels. Thus, the effect of elevated thyroid hormone levels on cross-sectional area, myofiber size, satellite cells, and myosin heavy chain (MyHC) isoform expression was examined in adult rabbit EOMs, to determine how elevated thyroid hormone alters EOM biology.
methodsAfter 1 month of elevated thyroid hormone levels, the EOMs were removed and prepared for histologic examination. Total muscle mass, myofiber size, patterns of MyHC isoform expression, and the number of satellite cells were determined.
resultsElevated thyroid hormone levels significantly decreased muscle mass, total number of myofibers, and mean cross-sectional area of the myofibers. Alterations in MyHC isoform expression were extremely complex, but several basic patterns emerged. The percentages of neonatal- and developmental-positive myofibers decreased in almost all EOM regions examined, and the percentages of slow-positive myofibers significantly increased. In contrast to normal EOMs, which retain a population of activated satellite cells throughout life, elevated thyroid hormone levels resulted in the virtual disappearance of MyoD-positive cells and a decrease in Pax7-positive cells.
conclusionsThe reductions in EOM size, number of fibers expressing developmental and neonatal MyHC, and number of MyoD- and Pax7-positive satellite cells suggest that elevated thyroid hormone levels decrease the ongoing myofiber remodeling normally seen in the EOM. These catabolic changes have important implications for maintenance of function in the EOMs.
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