ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Trial
- UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.Mechanisms of ageing and development · 2012Trial
- Genetic prediction of lower limb isometric strength changes after 12 weeks of resistance training.Biology of sport · 2025Article
- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.Genes · 2020Article
- Effects of resistance training on muscle strength, endurance, and motor unit according to ciliary neurotrophic factor polymorphism in male college students.Journal of sports science & medicine · 2014Article
- Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism.Journal of exercise nutrition & biochemistry · 2014Article
- Highlights from the functional single nucleotide polymorphisms associated with human muscle size and strength or FAMuSS study.BioMed research international · 2013Article
- Article
- Handgrip strength at midlife and familial longevity : The Leiden Longevity Study.Age (Dordrecht, Netherlands) · 2012Article
- Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults.Journal of strength and conditioning research · 2012Article
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The present study examined associations between the ciliary neurotrophic factor (CNTF) 1357 G --> A polymorphism and the muscle strength response to a unilateral, upper arm resistance-training (RT) program among healthy, young adults. Subjects were 754 Caucasian men (40%) and women (60%) who were genotyped and performed a training program of the nondominant (trained) arm with the dominant (untrained) arm as a comparison. Peak elbow flexor strength was measured with one repetition maximum, isometric strength with maximum voluntary contraction, and bicep cross-sectional area with MRI in the trained and untrained arms before and after training. Women with the CNTF GG genotype gained more absolute isometric strength, as measured by MVC (6.5 +/- 0.3 vs. 5.2 +/- 0.5 kg), than carriers of the CNTF A1357 allele in the trained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. Women with the CNTF GG genotype gained more absolute dynamic (1.0 +/- 0.1 vs. 0.6 +/- 0.1 kg) and allometric (0.022 +/- 0.0 vs. 0.015 +/- 0.0 kg/kg(-0.67)) strength, as measured by 1 RM, than carriers of the CNTF A1357 allele in the untrained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. No significant associations, as measured by cross-sectional area, were seen in men or women. The CNTF 1357 G --> A polymorphism explains only a small portion of the variability in the muscle strength response to training in women.
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Registered trials
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