ArticleProceedings of the National Academy of Sciences of the United States of America2009
Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Nanopore Studies of DNA Damage and G-quadruplex Folding in the Human Telomere Sequence.Chimia · 2026Article
- Distinguishing Isomeric Cyclobutane Thymidine Dimers by Ion Mobility and Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024Article
- Post- and Pre-Radiolabeling Assays forBiochemistry · 2023Article
- Stability of Human Telomeric G-Quadruplexes Complexed with Photosensitive Ligands and Irradiated with Visible Light.International journal of molecular sciences · 2023Article
- Photocrosslinking Probes Proximity of Thymine Modifiers Tethering Excitonically Coupled Dye Aggregates to DNA Holliday Junction.Molecules (Basel, Switzerland) · 2022Article
- Quantification of 8-International journal of molecular sciences · 2022Article
- G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story.International journal of molecular sciences · 2021Article
- Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex.The Journal of biological chemistry · 2020Article
- Studying the excited electronic states of guanine rich DNA quadruplexes by quantum mechanical methods: main achievements and perspectives.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2020Review
- Generation of 8-oxo-7,8-dihydroguanine in G-Quadruplexes Models of Human Telomere Sequences by One-electron Oxidation.Photochemistry and photobiology · 2019Article
- Photocrosslinking of G-Quadruplex-Forming Sequences found in Human Promoters.Photochemistry and photobiology · 2019Article
- RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain.Nucleic acids research · 2018Article
- Evidence for Reverse Hoogsteen Hairpin Intermediates in the Photocrosslinking of Human Telomeric DNA Sequences.Photochemistry and photobiology · 2018Article
- Folding and misfolding pathways of G-quadruplex DNA.Nucleic acids research · 2016Article
- DNA damage processing at telomeres: The ends justify the means.DNA repair · 2016Review
- Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts.Chemical Society reviews · 2015Review
- Single-molecule analysis of thymine dimer-containing G-quadruplexes formed from the human telomere sequence.Biochemistry · 2014Article
- Folding and unfolding pathways of the human telomeric G-quadruplex.Journal of molecular biology · 2014Article
- Effect of sequence and metal ions on UVB-induced anti cyclobutane pyrimidine dimer formation in human telomeric DNA sequences.Nucleic acids research · 2014Article
- Populated intermediates in the thermal unfolding of the human telomeric quadruplex.Journal of the American Chemical Society · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The unusual structural forms of telomere DNA, which protect the ends of chromosomes during replication, may render it vulnerable to unprecedented photodamage, possibly involving nonadjacent bases that are made proximate by folding. The G-quadruplex for the human telomere sequence consisting of a repeating d(TTAGGG) is one unusual form. Tel22, d[AGGG(TTAGGG)(3)], forms a basket structure in the presence of Na(+) and may form multiple equilibrating structures in the presence of K(+) with hybrid-type structures predominating. UVB irradiation of d[AGGG(TTAGGG)(3)] in the presence of Na(+) results in a cis,syn thymine dimer between two adjacent Ts in a TTA loop and a mixture of nonadjacent anti thymine dimers between various loops. Irradiation in the presence of K(+), however, produces, in addition to these same products, a large amount of specific anti thymine dimers formed between either T in loop 1 and the central T in loop 3. These latter species were not observed in the presence of Na(+). Interloop-specific anti thymine dimers are incompatible with hybrid-type structures, but could arise from a chair or basket-type structure or from triplex intermediates involved in interconverting these structures. If these unique nonadjacent anti thymine dimer photoproducts also form in vivo, they would constitute a previously unrecognized type of DNA photodamage that may interfere with telomere replication and present a unique challenge to DNA repair. Furthermore, these unusual anti photoproducts may be used to establish the presence of G-quadruplex or quadruplex-like structures in vivo.
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