ReviewThe journal of pain2009
Translational pain research: achievements and challenges.
Review in The journal of pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01623271 (Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analgesic effects of noninvasive brain stimulation in rodent animal models: a systematic review of translational findings.Neuromodulation : journal of the International Neuromodulation Society · 2012Pooled it
- Effects ofPain reports · 2026Article
- Microtubule Cytoskeleton Dysfunction in Chronic Pain: Mechanisms of Transport Failure and Emerging Therapeutic Targets.International journal of molecular sciences · 2026Review
- Role of perioperative ketamine on the incidence of rebound pain after regional nerve block in the adult surgical population: A systematic review and meta-analysis of randomised controlled trials.Indian journal of anaesthesia · 2026Article
- Objective Measurement of Musculoskeletal Pain: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- What makes life go well? A network topic modeling analysis of well-being practices in adults with chronic pain.Pain medicine (Malden, Mass.) · 2025Article
- Advancing research translation in addiction and pain: A portfolio analysis of the NIH HEAL initiative.Journal of clinical and translational science · 2025Article
- The excessive generalization of fear affected by perceptual bias in experimental pain individuals: Evidence from an event-related potential study.Brain and behavior · 2023Article
- Article
- Editorial: Translational research in neuropathic pain: Current status and future directions.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Combining Electrodermal Activity With the Peak-Pain Time to Quantify Three Temporal Regions of Pain Experience.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Brain mechanisms of chronic pain: critical role of translational approach.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Neuromuscular adaptations to experimentally induced pain in the lumbar region: protocol for a systematic review and meta-analysis.Systematic reviews · 2021Article
- [Establishment of an adaptable acute pain model for induction of nociceptive stimuli of defined intensity and duration using thermal stimulation].Schmerz (Berlin, Germany) · 2020Article
- The emergence of animal models of chronic pain and logistical and methodological issues concerning their use.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Article
- Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice.Neuropharmacology · 2018Article
- Article
- Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma.Journal of pain research · 2017Article
- Functional magnetic resonance imaging of the cervical spinal cord during thermal stimulation across consecutive runs.NeuroImage · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
unlabelledThe achievements in both preclinical and clinical pain research over the past 4 decades have led to significant progress in clinical pain management. However, pain research still faces enormous challenges and there remain many obstacles in the treatment of clinical pain, particularly chronic pain. Translational pain research needs to involve a number of important areas including: 1) bridging the gap between pain research and clinical pain management; 2) developing objective pain-assessment tools; 3) analyzing current theories of pain mechanisms and their relevance to clinical pain; 4) exploring new tools for both preclinical and clinical pain research; and 5) coordinating research efforts among basic scientists, clinical investigators, and pain-medicine practitioners. These issues are discussed in this article in light of the achievements and challenges of translational pain research. PERSPECTIVE: The subjective nature of clinical pain calls for innovative research approaches. As translational pain research emerges as an important field in pain medicine, it will play a unique role in improving clinical pain management through coordinated bidirectional research approaches between bedside and bench.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.