ArticleSchizophrenia research2009
Event-related potential abnormalities in schizophrenia: a failure to "gate in" salient information?
Article in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 91 citations in OpenAlex.
- Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors.Neuroscience · 2013Trial
- The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine.Neuroscience · 2011Trial
- Development of a Human Electrophysiology Laboratory to Advance Cognitive Neuroscience in Western Kenya.Clinical EEG and neuroscience · 2026Article
- Auditory gating and its clinical correlates in adults with chronic tic disorder and neurotypical adults.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview.Advances in neurobiology · 2024Review
- Is a paired-stimuli configuration necessary to obtain typical evoked response differences in studies of psychosis? An MEG study.Biomarkers in neuropsychiatry · 2021Article
- P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients.Frontiers in psychiatry · 2020Article
- Delta Vs Gamma Auditory Steady State Synchrony in Schizophrenia.Schizophrenia bulletin · 2018Article
- Multidimensional Connectomics and Treatment-Resistant Schizophrenia: Linking Phenotypic Circuits to Targeted Therapeutics.Frontiers in psychiatry · 2018Review
- Inhibitory Control Impairment on Somatosensory Gating Due to Aging: An Event-Related Potential Study.Frontiers in human neuroscience · 2018Article
- Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders.Schizophrenia bulletin · 2017Article
- Gamma band oscillations: a key to understanding schizophrenia symptoms and neural circuit abnormalities.Current opinion in psychiatry · 2016Review
- Effects of Stimulus-Driven and Goal-Directed Attention on Prepulse Inhibition of Brain Oscillations.Frontiers in human neuroscience · 2016Article
- Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating.Frontiers in human neuroscience · 2016Article
- Brain rhythms connect impaired inhibition to altered cognition in schizophrenia.Biological psychiatry · 2015Review
- Sensory gating disturbances in the spectrum: similarities and differences in schizotypal personality disorder and schizophrenia.Schizophrenia research · 2015Article
- Article
- Relation of frontal N100 to psychopathy-related differences in selective attention.Biological psychology · 2014Article
- Critical evaluation of auditory event-related potential deficits in schizophrenia: evidence from large-scale single-subject pattern classification.Schizophrenia bulletin · 2014Article
- Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension.Schizophrenia bulletin · 2014Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Sensory gating refers to the central nervous system's ability to filter sensory inputs, and can be measured by comparing the suppression of event-related brain potential (ERP) amplitudes in a paired auditory stimulus procedure. Poor gating scores in schizophrenia may be caused by abnormal responses to the first (S1), the second (S2) or both of the paired stimuli. However, since S1 and S2 responses may index separate psychological phenomenon, corresponding to the ability to "gate in" and "gate out" sensory stimuli respectively, the precise mechanism affected in schizophrenia remains unclear. To examine the extent to which saliency processing abnormalities may contribute to S1 response deficits, standard and rare (15% probability) paired stimuli were presented to 21 participants with schizophrenia and 22 healthy controls. P50 and N100 ERP amplitude as well as low, beta and gamma frequency power were measured to examine the time course and relative contributions of oscillatory activity affecting auditory processing in schizophrenia. In this study, schizophrenia patients exhibited less evoked beta 1 power (12-20 Hz) in response to salient stimuli at S1, and lower N100 amplitude in response to all S1 stimuli. No group differences were found in the low, beta 2 (20-30 Hz), or gamma frequency ranges. These findings suggest aberrant sensory processing during stages of stimulus evaluation and saliency detection in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.