ReviewAdvanced drug delivery reviews2009
"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides.
Review in Advanced drug delivery reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development.Molecules (Basel, Switzerland) · 2022Review
- The Potential of the Cyclotide Scaffold for Drug Development.Biomedicines · 2019Review
- Using backbone-cyclized Cys-rich polypeptides as molecular scaffolds to target protein-protein interactions.The Biochemical journal · 2019Review
- In-cell production of a genetically-encoded library based on the θ-defensin RTD-1 using a bacterial expression system.Bioorganic & medicinal chemistry · 2018Article
- Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis.Scientific reports · 2017Article
- Recombinant Expression of Cyclotides Using Split Inteins.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing.Biopolymers · 2016Article
- Peptide aptamers: development and applications.Current topics in medicinal chemistry · 2015Review
- Intein applications: from protein purification and labeling to metabolic control methods.The Journal of biological chemistry · 2014Review
- Recombinant expression of backbone-cyclized polypeptides.Biopolymers · 2013Review
- The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme.The Journal of biological chemistry · 2013Article
- Recent progress in intein research: from mechanism to directed evolution and applications.Cellular and molecular life sciences : CMLS · 2013Review
- Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions.Angewandte Chemie (International ed. in English) · 2013Article
- Biological synthesis of circular polypeptides.The Journal of biological chemistry · 2012Review
- Peptide bicycles that inhibit the Grb2 SH2 domain.Chembiochem : a European journal of chemical biology · 2012Article
- Host-defense activities of cyclotides.Toxins · 2012Review
- Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins.Biochemistry · 2011Article
- Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.Current pharmaceutical design · 2011Review
- Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy.Journal of medicinal chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The present paper reviews the use of protein splicing for the biosynthesis of backbone cyclic polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the possibility to generate cell-based combinatorial libraries that can be screened inside living cells for their ability to attenuate or inhibit cellular processes thus providing a new way for finding therapeutic agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.