ReviewAdvanced drug delivery reviews2009
Environmentally responsive peptides as anticancer drug carriers.
Review in Advanced drug delivery reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Enhanced pharmacokinetic and therapeutic of GSH-responsive mPEG-Frontiers in pharmacology · 2025Article
- The use of nanomaterials as drug delivery systems and anticancer agents in the treatment of triple-negative breast cancer: an updated review (year 2005 to date).Discover nano · 2024Review
- Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis.Journal of biomedical science · 2024Review
- The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials.Drug delivery · 2021Review
- Bio-Orthogonal Nanogels for Multiresponsive Release.Biomacromolecules · 2021Article
- Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin.Drug delivery · 2020Article
- Novel nano-pomegranates based on astragalus polysaccharides for targeting ERα-positive breast cancer and multidrug resistance.Drug delivery · 2020Article
- Optimization and Evaluation of Poly(lactide-Pharmaceutics · 2020Article
- Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures.Frontiers in chemistry · 2020Review
- Article
- Immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment.OncoTargets and therapy · 2018Review
- Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment.Science and technology of advanced materials · 2018Review
- Bifunctional Elastin-like Polypeptide Nanoparticles Bind Rapamycin and Integrins and Suppress Tumor Growth in Vivo.Bioconjugate chemistry · 2017Article
- Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth.Chemical science · 2017Article
- "A novel highly stable and injectable hydrogel based on a conformationally restricted ultrashort peptide".Scientific reports · 2016Article
- PEG-polypeptide block copolymers as pH-responsive endosome-solubilizing drug nanocarriers.Molecular pharmaceutics · 2014Article
- A quantitative recipe for engineering protein polymer nanoparticles.Polymer chemistry · 2014Article
- Kinetic quantification of protein polymer nanoparticles using non-invasive imaging.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Bombesin analogue-mediated delivery preferentially enhances the cytotoxicity of a mitochondria-disrupting peptide in tumor cells.PloS one · 2013Article
- A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains.Biomacromolecules · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The tumor microenvironment provides multiple cues that may be exploited to improve the efficacy of established chemotherapeutics; furthermore, polypeptides are uniquely situated to capitalize on these signals. Peptides provide: 1) a rich repertoire of biologically specific interactions to draw upon; 2) environmentally responsive phase behaviors, which may be tuned to respond to signatures of disease; 3) opportunities to direct self-assembly; 4) control over routes of biodegradation; 5) the option to seamlessly combine functionalities into a single polymer via a one-step biosynthesis. As development of cancer-targeted nanocarriers expands, peptides provide a unique source of functional units that may target disease. This review explores potential microenvironmental physiology indicative of tumors and peptides that have demonstrated an ability to target and deliver to these signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.