ArticleArthritis research & therapy2009
Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort.
Article in Arthritis research & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- The characteristics of peripheral blood lymphocyte main subsets in rheumatoid arthritis patients concurrent with hepatitis b virus infection: a retrospective cohort study.BMC infectious diseases · 2025Article
- Serum and urine free light chains measurements in patients with systemic sclerosis: novel biomarkers for disease activity.Clinical and experimental immunology · 2021Article
- Serum markers of B-cell activation in pregnancy during late gestation, delivery, and the postpartum period.American journal of reproductive immunology (New York, N.Y. : 1989) · 2019Article
- Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid.PloS one · 2019Article
- Soluble Markers of Antibody Secreting Cell Function as Predictors of Infection Risk in Rheumatoid Arthritis.Journal of immunology research · 2019Article
- Phenotypic characterization of patients with rheumatologic manifestations of common variable immunodeficiency.Seminars in arthritis and rheumatism · 2018Article
- Urinary free light chains may help to identify infection in patients with elevated systemic inflammation due to rheumatic disease.Rheumatology international · 2017Article
- B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis.PloS one · 2017Article
- VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.Genes and immunity · 2017Article
- The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease.Clinical rheumatology · 2016Article
- Changes in peripheral blood lymphocyte subsets during arthritis development in arthralgia patients.Arthritis research & therapy · 2016Article
- Elevation of serum immunoglobulin free light chains during the preclinical period of rheumatoid arthritis.The Journal of rheumatology · 2015Article
- Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging.Current aging science · 2015Review
- Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis.Journal of inflammation (London, England) · 2015Article
- Memory B cell subsets and plasmablasts are lower in early than in long-standing rheumatoid arthritis.BMC immunology · 2014Article
- B cells in rheumatoid arthritis: from pathogenic players to disease biomarkers.BioMed research international · 2014Review
- TSPAN33 is a novel marker of activated and malignant B cells.Clinical immunology (Orlando, Fla.) · 2013Article
- Elevated pretransplantation soluble BAFF is associated with an increased risk of acute antibody-mediated rejection.Transplantation · 2013Article
- Curcumin protects against collagen-induced arthritis via suppression of BAFF production.Journal of clinical immunology · 2013Article
- Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease.International journal of rheumatology · 2013Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLittle is known about systemic B-cell activation in early rheumatoid arthritis (RA). We therefore evaluated the serum levels of markers of B-cell activation in patients included in the ESPOIR early arthritis cohort.
methodsIn the ESPOIR early arthritis cohort (at least 2 swollen joints for more than 6 weeks but less than 6 months), 710 patients were assessed at 1 year and either met the 1987 American College of Rheumatology criteria for RA (n = 578) or had undifferentiated arthritis (n = 132). Baseline serum samples of patients naïve to corticosteroid and disease-modifying antirheumatic drug treatment were assessed for beta2-microglobulin, IgG, IgA, IgM, immunoglobulin free light chains of immunoglobulins, and B-cell activating factor of the tumor necrosis factor family (BAFF). The BAFF gene 871T>C polymorphism was genotyped in all patients.
resultsAll markers of B-cell activation except BAFF and IgM were significantly higher in patients with early RA than those with undifferentiated arthritis. Anti-cyclic citrullinated peptide (anti-CCP) and beta2-microglobulin were associated with a diagnosis of early RA in the multivariate analysis. Markers of B-cell activation, except BAFF, were associated with disease activity, rheumatoid factor and anti-CCP secretion. The BAFF gene polymorphism was not associated with early RA.
conclusionsMarkers of B-cell activation are elevated in patients with early RA, compared with undifferentiated arthritis, independently of any systemic increase in BAFF secretion, and correlate with disease activity. This study sheds new light on the early pathogenic role of B-lymphocytes in RA and suggests that targeting them might be a useful therapeutic strategy in early RA.
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