ArticleBMC biology2009
Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes.
Article in BMC biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- ParaHox Genes Revisited: From Gut Patterning to Integrated Axial and Neural Organization in Rotifera.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Patterns of Conservation and Loss of Hox Genes in Xenacoelomorph Lineage Since Divergence From Last Common Bilaterian Ancestor.Genome biology and evolution · 2026Article
- Octopod Hox genes and cephalopod plesiomorphies.Scientific reports · 2023Article
- Article
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Non-collinear Hox gene expression in bivalves and the evolution of morphological novelties in mollusks.Scientific reports · 2021Article
- Horseshoe crab genomes reveal the evolution of genes and microRNAs after three rounds of whole genome duplication.Communications biology · 2021Article
- Millipede genomes reveal unique adaptations during myriapod evolution.PLoS biology · 2020Article
- Mutation of amphioxus Pdx and Cdx demonstrates conserved roles for ParaHox genes in gut, anus and tail patterning.BMC biology · 2020Article
- Signatures of Divergence, Invasiveness, and Terrestrialization Revealed by Four Apple Snail Genomes.Molecular biology and evolution · 2019Article
- Transcriptome Analysis of Larval Segment Formation and Secondary Loss in the Echiuran WormInternational journal of molecular sciences · 2019Article
- A Revised Spiralian Homeobox Gene Classification Incorporating New Polychaete Transcriptomes Reveals a Diverse TALE Class and a Divergent Hox Gene.Genome biology and evolution · 2018Article
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- Article
- A transcriptional blueprint for a spiral-cleaving embryo.BMC genomics · 2016Article
- TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates.BMC evolutionary biology · 2016Article
- Hox and ParaHox gene expression in early body plan patterning of polyplacophoran mollusks.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2016Article
- The niche in single-cell technologies.Immunology and cell biology · 2016Review
- Article
- Molecular regionalization in the compact brain of the meiofaunal annelid Dinophilus gyrociliatus (Dinophilidae).EvoDevo · 2016Article
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundThe ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the more recently discovered ParaHox cluster. ParaHox gene clustering, and its relationship to expression, has only been described in deuterostomes. Conventional protostome models (Drosophila melanogaster and Caenorhabditis elegans) are secondarily derived with respect to ParaHox genes, suffering gene loss and cluster break-up.
resultsWe provide the first evidence for ParaHox gene clustering from a less-derived protostome animal, the annelid Platynereis dumerilii. Clustering of these genes is thus not a sole preserve of the deuterostome lineage within Bilateria. This protostome ParaHox cluster is not entirely intact however, with Pdu-Cdx being on the opposite end of the same chromosome arm from Pdu-Gsx and Pdu-Xlox. From the genomic sequence around the P. dumerilii ParaHox genes the neighbouring genes are identified, compared with other taxa, and the ancestral arrangement deduced.
conclusionWe relate the organisation of the ParaHox genes to their expression, and from comparisons with other taxa hypothesise that a relatively complex pattern of ParaHox gene expression existed in the protostome-deuterostome ancestor, which was secondarily simplified along several invertebrate lineages. Detailed comparisons of the gene content around the ParaHox genes enables the reconstruction of the genome surrounding the ParaHox cluster of the protostome-deuterostome ancestor, which existed over 550 million years ago.
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