ReviewOrthodontics & craniofacial research2009
Pathways in external apical root resorption associated with orthodontia.
Review in Orthodontics & craniofacial research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
- Automated deep learning detection of orthodontically induced external apical root resorption in maxillary incisors on panoramic radiographs.Progress in orthodontics · 2026Article
- Partial cementocyte ablation does not reduce cellular cementum apposition in a mouse model of molar super-eruption.Bone reports · 2025Article
- Microdamage in biological hard tissues and its repair mechanisms.Biomedical engineering online · 2025Review
- Salivary and gingival crevicular fluid (GCF) protein biomarkers as proxies of root resorption following orthodontic tooth movement. A systematic review.Journal of clinical and experimental dentistry · 2025Review
- Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review.Korean journal of orthodontics · 2024Article
- External apical root resorption in African American orthodontic patients.European journal of orthodontics · 2024Article
- Genetic and other factors contributing to external apical root resorption in orthodontic patients.Orthodontics & craniofacial research · 2023Article
- Investigation of Forces and Moments during Orthodontic Tooth Intrusion Using Robot Orthodontic Measurement and Simulation System (ROSS).Bioengineering (Basel, Switzerland) · 2023Article
- Necrotic Pulp With Crown Discoloration Associated With Orthodontic Treatment: A Case Report.Cureus · 2023Article
- The Prevalence of Root Resorption after Orthodontic Treatment in Patients Attending a University Hospital Dental Clinic.Journal of pharmacy & bioallied sciences · 2021Article
- Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption.Journal of clinical medicine · 2021Article
- Polymorphisms of Encoding GenesInternational journal of molecular sciences · 2021Article
- Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption.Scientific reports · 2020Article
- External apical root resorption in orthodontic patients: molecular and genetic basis.Journal of family medicine and primary care · 2020Review
- Root resorption and ensuing cementum repair by Wnt/β-catenin dependent mechanism.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2020Article
- Actin and Actin-Associated Proteins in Extracellular Vesicles Shed by Osteoclasts.International journal of molecular sciences · 2019Review
- MicroRNA Expression Profiles in External Cervical Resorption.Journal of endodontics · 2019Article
- Markers in blood and saliva for prediction of orthodontically induced inflammatory root resorption: a retrospective case controlled-study.Progress in orthodontics · 2017Article
- Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped?Seminars in orthodontics · 2017Article
- A preliminary investigation of short-term cytokine expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study.Progress in orthodontics · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
To review studies investigating if genetic factors play a role in external apical root resorption (EARR) during orthodontic treatment. Heritability estimation in human sib-pairs, comparison of multiple inbred mouse strains, human sib-pair linkage and parents-child trio association studies, and two gene (Il-1b, and P2rx7) knock out mouse models. Heritability for EARR of the maxillary central incisors concurrent with orthodontic treatment is 0.8. DBA/2J, BALB/cJ, and 129P3/J inbred mouse strains are highly susceptible (p < .05) to histological root resorption (RR) associated with orthodontic force (RRAOF), whereas A/J, C57BL/6J and SJL/J mice are resistant. Non-parametric sibling pair linkage analysis identified evidence of linkage (LOD = 2.5; p = 0.02) of EARR with microsatellite D18S64 (tightly linked to TNFRSF11A, also known as RANK). There is significant linkage disequilibrium of IL-1B (p = 0.0003), and OPG (p = 0.003) with EARR. RRAOF increases in Il1b KO (p < or = 0.013), and increases in P2rx7 KO (p < 0.02) mice compared to wild-type. Genetic factors play a marked role in EARR concurrent with orthodontic force, accounting for one-half to two-thirds of the variation. Two pathways for this may involve: 1) activation control of osteoclasts through the ATP/P2XR7/IL-1B inflammation modulation pathway; and 2) RANK/RANKL/OPG osteoclast activation control. Histological RR occurs and is typically healed. If resorption outpaces healing, then EARR develops. Normal and parafunctional forces, as well as orthodontic forces, may add to or interact with the individual's susceptibility to pass the threshold of developing EARR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.