ArticleOrthodontics & craniofacial research2009
Differential gene expression in the perichondrium and cartilage of the neonatal mouse temporomandibular joint.
Article in Orthodontics & craniofacial research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Changes in Disc Status and Condylar Regeneration After Intracapsular Condylar Fractures in Rabbits.Oral diseases · 2025Article
- Morphological and Molecular Evaluation of the Tissue Repair following Nasal Septum Biopsy in a Sheep Model.Cartilage · 2021Article
- Implications of zonal architecture on differential gene expression profiling and altered pathway expressions in mandibular condylar cartilage.Scientific reports · 2021Article
- Understanding Early-Stage Posttraumatic Osteoarthritis for Future Prospects of Diagnosis: from Knee to Temporomandibular Joint.Current osteoporosis reports · 2021Review
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- Crosstalk between Fas and S1PThe Japanese dental science review · 2019Review
- Optimizing Laser Capture Microdissection Protocol for Isolating Zone-Specific Cell Populations from Mandibular Condylar Cartilage.International journal of dentistry · 2019Article
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- Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis.Current rheumatology reviews · 2018Review
- iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage induced by reducing dietary loading.Frontiers of medicine · 2017Article
- Mouse genetic models for temporomandibular joint development and disorders.Oral diseases · 2016Review
- Progenitor Cells of the Mandibular Condylar Cartilage.Current molecular biology reports · 2015Article
- Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth.Osteoarthritis and cartilage · 2014Article
- Growth factor stimulation improves the structure and properties of scaffold-free engineered auricular cartilage constructs.PloS one · 2014Article
- Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible.European journal of histochemistry : EJH · 2012Article
- Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Isolation and characterization of murine mandibular condylar cartilage cell populations.Cells, tissues, organs · 2012Article
- Cell fate mediators Notch and Twist in mouse mandibular condylar cartilage.Archives of oral biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Our goal was to discover genes differentially expressed in the perichondrium (PC) of the mandibular condylar cartilage (MCC) that might enhance regenerative medicine or orthopaedic therapies directed at the tissues of the temporomandibular joint. We used targeted gene arrays (osteogenesis, stem cell) to identify genes preferentially expressed in the PC and the cartilaginous (C) portions of the MCC in 2-day-old mice. Genes with higher expression in the PC sample related to growth factor ligand-receptor interactions [FGF-13 (6.4x), FGF-18 (4x), NCAM (2x); PGDF receptors, transforming growth factor (TGF)-beta and IGF-1], the Notch isoforms (especially Notch 3 and 4) and their ligands or structural proteins/proteoglycans [collagen XIV (21x), collagen XVIII (4x), decorin (2.5x)]. Genes with higher expression in the C sample consisted mostly of known cartilage-specific genes [aggrecan (11x), procollagens X (33x), XI (14x), IX (4.5x), Sox 9 (4.4x) and Indian hedgehog (6.7x)]. However, the functional or structural roles of several genes that were expressed at higher levels in the PC sample are unclear [myogenic factor (Myf) 9 (9x), tooth-related genes such as tuftelin (2.5x) and dentin sialophosphoprotein (1.6x), VEGF-B (2x) and its receptors (3-4x) and sclerostin (1.7x)]. FGF, Notch and TGF-beta signalling may be important regulators of MCC proliferation and differentiation; the relatively high expression of genes such as Myf6 and VEGF-B and its receptors suggests a degree of unsuspected plasticity in PC cells.
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Registered trials
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