ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Optimization and validation of radionuclide angiography phase analysis parameters for quantification of mechanical dyssynchrony.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- SimultaneousClinics (Sao Paulo, Brazil) · 2025Article
- Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Towards pre-treatment imaging prediction of chemotherapy-related cardiotoxicity.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Single-photon cardiac imaging in patients with cardiac implantable electrical devices.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Prognostic value of left-ventricular systolic and diastolic dyssynchrony measured from gated SPECT MPI in patients with dilated cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative overview.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- The role of nuclear medicine in assessments of cardiac dyssynchrony.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Phase analysis of gated blood pool SPECT for multiple stress testing assessments of ventricular mechanical dyssynchrony in a tachycardia-induced dilated cardiomyopathy canine model.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Assessment of left ventricular mechanical dyssynchrony by phase analysis of gated-SPECT myocardial perfusion imaging and tissue Doppler imaging: comparison between QGS and ECTb software packages.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Cardiac dyssynchrony: we have the tools. It is time to use them.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Evaluation of baseline contractile reserve vs dyssynchrony as a predictor of functional improvement and long term outcome after resynchronization pacing therapy: a radionuclide stress study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Nonechocardiographic imaging in evaluation for cardiac resynchronization therapy.Circulation. Cardiovascular imaging · 2011Review
- SPECT blood pool phase analysis can accurately and reproducibly quantify mechanical dyssynchrony.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Relation of left-ventricular dyssynchrony by phase analysis of gated SPECT images and cardiovascular events in patients with implantable cardiac defibrillators.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
- Cardiac resynchronization therapy; the importance of evaluating cardiac metabolism.The international journal of cardiovascular imaging · 2010Article
- Cardiac resynchronization therapy; evaluation by advanced imaging techniques.The international journal of cardiovascular imaging · 2010Article
- Imaging synchrony.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Abstract
introductionCardiac resynchronization therapy (CRT) has the potential to improve the outcome of patients suffering from mechanical dyssynchrony and heart failure. It has been suggested that accurate quantification of baseline extent of mechanical dyssynchrony may lead to pre-selection of patients likely to respond to CRT. The standard deviation from a phase histogram (phaseSD), synchrony (S) and entropy (E) are parameters obtained from phase analysis of planar radionuclide angiography (RNA) that may provide an accurate means of assessing mechanical dyssynchrony. In this paper, the ability of phaseSD, S, and E to detect mechanical dyssynchrony was investigated and optimal values for image smoothing, histogram noise thresholding, and bin size were defined. Finally, the intra- and inter-observer reproducibility of the methodology was assessed.
methodsPhaseSD, S, and E were calculated for 37 normal subjects (LVEF > 50%, end-diastolic volume < 120 mL, end-systolic volume < 60 mL, QRS < 120 ms, and normal wall motion) and 53 patients with mechanical dyssynchrony (LVEF < 30%, QRS > 120 ms, and typical LBBB). Receiver-operator characteristics (ROC) curves were created and the area under the curve (AUC), for each parameter, was determined using three different imaging filters (no filter and an order 5 Hann filter with cut-off of 5/50 and 10/50). The AUC was also determined using histogram threshold values varying between 0% and 50% (of the max amplitude value). Finally, AUC for E was determined for bins sizes varying between 1 degrees and 20 degrees . Inter- and intra-observer variability was calculated at optimal imaging values.
resultsNo smoothing was found to maximize the AUC. The AUC was independent of histogram threshold value. However, a value of 20% provided optimal visualization of the phase image. The AUC was also independent of bin size. At the optimal imaging values, the sensitivity and specificity for all parameters for detection of mechanical dyssynchrony was measured to be 89-100%. Inter- and intra-observer correlation coefficients >0.99 were found for phaseSD, S and E.
conclusionsOptimized planar RNA phase analysis parameters, phaseSD, S, and E, were able to detect mechanical dyssynchrony with low inter- and intra-observer variability. Studies assessing the ability of these parameters to predict CRT outcome are required.
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