Evidence map›Paper›PMID 19626208›Full record

ArticleDeutsches Arzteblatt international2008

Pain therapy in children and adolescents.

Boris Zernikow, Tanja Hechler

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Deutsches Arzteblatt international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02914405 (A Phase I Study of 131-1 mIBG Followed by Nivolumab and Dinutuximab Beta in Children With Relapsed/Refractory Neuroblastoma), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02914405 phase1active not recruitingnot on this mapstarted 2018, after this paper: background citation

A Phase I Study of 131-1 mIBG Followed by Nivolumab and Dinutuximab Beta in Children With Relapsed/Refractory Neuroblastoma

TypeinterventionalSponsorUniversity Hospital Southampton NHS Foundation TrustRan2018 to 2026Enrolled44ConditionsNeuroblastomaArmsNivolumab, Ch14.18/CHO
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Paracetamol: a focus for the general pediatrician.European journal of pediatrics · 2014
    Review
  10. Article
  11. Article
  12. Article
  13. [Juvenile arthritides].Zeitschrift fur Rheumatologie · 2010
    Review
  14. Review
  15. Placebo: misunderstandings and prejudices.Deutsches Arzteblatt international · 2009
    Review
  16. Advise against metamizole.Deutsches Arzteblatt international · 2009
    Article
  17. Mention the ophthalmologist.Deutsches Arzteblatt international · 2009
    Article
  18. Current data situation.Deutsches Arzteblatt international · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Boris ZernikowVodafone Stiftungsinstitut für Kinderschmerztherapie und Pädiatrische Palliativmedizin, Vestische Kinder- und Jugendklinik, Universität Witten/Herdecke.
Tanja Hechler
Witten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn children, acute pain occurs predominantly during infectious illnesses or after surgery. Chronic pain, especially headache and abdominal pain, is becoming increasingly common among children and adolescents.

methodsSelective literature review, also including evidence-based guidelines and recommendations.

resultsSimple self-reporting and behavioral pain scales are easy to use to assess the intensity of acute pain. To evaluate chronic pain, on the other hand, more complicated, multi-dimensional instruments are necessary (e.g., semi-structured interviews). The most commonly used analgesics are ibuprofen and paracetamol (acetaminophen). When paracetamol is used, its narrow therapeutic window should be kept in mind. Perioperative pain should be treated with balanced analgesia involving a combination of non-pharmacological treatment strategies, non-opioid drugs, opioids, and regional anesthesia. Chronic pain in children can only be treated successfully over the long term with multidisciplinary team intervention based on this biopsychosocial model. DISCUSSION: Pain not only causes children momentary suffering but also threatens to impair their normal development. Therefore, every effort should be made to prevent pain and to treat it effectively once it arises.

Indexed as

adolescentschildrenmedicationpainpain scaletreatment

Identifiers

PMID19626208
PMCPMC2696927
OpenAlexW2105259824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.