Evidence map›Paper›PMID 19626043›Full record

Trial reportJournal of human hypertension2010

DASH lowers blood pressure in obese hypertensives beyond potassium, magnesium and fibre.

Y Al-Solaiman, A Jesri, W K Mountford, D T Lackland, Y Zhao, B M Egan

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of human hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The importance of potassium in managing hypertension.Current hypertension reports · 2011
    Pooled it
  6. Trial
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  12. Article
  13. Food as Medicine for Hypertension: Microbiota as Mediators.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
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  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Y Al-SolaimanDepartment of Medicine, Medical University of South Carolina, Charleston, SC, USA.
A Jesri
W K Mountford
D T Lackland
Y Zhao
B M Egan
Medical University of South Carolina · US

Funding

ZINC AND COPPER METABOLISM IN COLLAGEN DISORDERSM01RR001070 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI REVES, JOSEPH G · 1985 to 2009
$16.3M
ResearchP60MD000267 · NIMHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SLAUGHTER, SABRA CONWAY · 2002 to 2006
$3.7M
FATTY ACIDS EFFECTS ON VASCULAR REACTIVITYR01HL058794 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI EGAN, BRENT M · 1997 to 2004
$1.4M
INSULIN RESISTANCE AND CARDIOVASCULAR RISK FACTORSK24HL004290 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI EGAN, BRENT M · 2000 to 2004
$654k
NCRR NIH HHS M01 RR001070NCRR NIH HHS RR-01070NHLBI NIH HHS HL04290NHLBI NIH HHS HL58794NHLBI NIH HHS K24 HL004290NHLBI NIH HHS R01 HL058794NIMHD NIH HHS MD00267NIMHD NIH HHS P60 MD000267
6 · The paper itself

Abstract

The mechanism underlying blood pressure (BP) reduction in the high fruits and vegetables arm of the Dietary Approaches to Stop Hypertension (DASH) study is unknown but may include potassium, magnesium and fibre. This study was designed to separate minerals and fibre from other components of DASH on BP in abdominally obese individuals with metabolic syndrome with pre-hypertension to stage 1 hypertension (obese hypertensives). A total of 15 obese hypertensives and 15 lean normotensives were studied on a standardized usual diet, randomized to DASH or usual diet supplemented with potassium, magnesium and fibre to match DASH, then crossed over to the complementary diet. All diets were 3 weeks long, isocaloric and matched for sodium and calcium. In obese hypertensives, BP was lower after 3 weeks on DASH than usual diet (-7.6+/-1.4/-5.3+/-1.4 mm Hg, P<0.001/0.02) and usual diet supplemented (-6.2+/-1.4/-3.7+/-1.4 P<0.005/0.06), whereas BP was not significantly different on usual and supplemented diets. BP values were not different among the three diets in lean normotensives. Small artery elasticity was lower in obese hypertensives than in lean normotensives on the usual and supplemented diets (P<0.02). This index of endothelial function improved in obese hypertensives (P<0.02) but not lean normotensives on DASH, and was no longer different from values in lean normotensives (P>0.50). DASH is more effective than potassium, magnesium and fibre supplements for lowering BP in obese hypertensives, which suggest that high fruits and vegetables DASH lowers BP and improves endothelial function in this group by nutritional factors in addition to potassium, magnesium and fibre.

Indexed as

Blood PressureAdultAortaBiomarkersCalcium, DietaryDietary FiberElasticityEndothelium, VascularFemaleFruitHumansHypertensionMagnesiumMaleMetabolic SyndromeMiddle AgedBiomarkersCalcium, DietaryDietary FiberMagnesiumPotassium, DietarySodium, Dietary

Identifiers

PMID19626043
PMCPMC2841705
OpenAlexW1966821491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.