ReviewKidney international2009
Steroid-free maintenance immunosuppression in kidney transplantation: is it time to consider it as a standard therapy?
Review in Kidney international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Heat shock protein 90 is a new potential target of anti-rejection therapy in allotransplantation.Cell stress & chaperones · 2022Article
- Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney.Tissue engineering and regenerative medicine · 2019Article
- Causes of late transplant failure in cyclosporine-treated kidney allograft recipients.Clinical and experimental nephrology · 2019Article
- Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.Nature communications · 2019Article
- Impact of low-dose steroids on HbA1c levels and development of pre-diabetes and NODAT in non-diabetic renal transplant recipients on long-term follow-up.International urology and nephrology · 2018Article
- Graft outcomes following immunosuppressive therapy with different combinations in kidney transplant recipients: a nationwide cohort study.Therapeutics and clinical risk management · 2018Article
- Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation.Oncotarget · 2017Review
- National Variation in Use of Immunosuppression for Kidney Transplantation: A Call for Evidence-Based Regimen Selection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Article
- In vivo regeneration of renal vessels post whole decellularized kidneys transplantation.Oncotarget · 2015Article
- The effective bioengineering method of implantation decellularized renal extracellular matrix scaffolds.Oncotarget · 2015Article
- Immunosuppressant dose reduction and long-term rejection risk in renal transplant recipients with severe bacterial pneumonia.Singapore medical journal · 2014Article
- Kidney transplantation with early corticosteroid withdrawal: paradoxical effects at the central and peripheral skeleton.Journal of the American Society of Nephrology : JASN · 2014Article
- Three-year outcomes in kidney transplant patients randomized to steroid-free immunosuppression or steroid withdrawal, with enteric-coated mycophenolate sodium and cyclosporine: the infinity study.Journal of transplantation · 2014Article
- Influence of steroid maintenance on the outcomes in deceased donor kidney transplant recipients experiencing delayed graft function.Indian journal of nephrology · 2013Article
- Physiological functions and clinical implications of fibrinogen-like 2: A review.World journal of clinical infectious diseases · 2013Article
- Recurrence of anti-neutrophil cytoplasmic antibody-associated vasculitis in appropriately immunosuppressed renal transplant patients: a discussion of two cases.Case reports in nephrology and urology · 2013Article
- Reduced fracture risk with early corticosteroid withdrawal after kidney transplant.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Ten-year outcome after rapid discontinuation of prednisone in adult primary kidney transplantation.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- B-cell tolerance in transplantation: is repertoire remodeling the answer?Expert review of clinical immunology · 2009Article
- Effectiveness of steroid-free immunosuppressive regimens after kidney transplantation: the pioneering experience of a brazilian center.Jornal brasileiro de nefrologiaArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Steroid-free immunosuppression in kidney transplantation has been gaining popularity over the past decade, as documented by a continuous and steady rise in the number of kidney transplant patients discharged on steroid-free regimens. This increased interest in steroid-free immunosuppression is fueled by the recognition that half of transplant loss is related to patient death due to cardiovascular disease and/or infectious complications and that the long-term use of steroids contributes to such elevated cardiovascular morbidity and mortality. The availability of newer and more potent immunosuppressive agents has furthered such interest. Many clinical trials over the past two decades have demonstrated the feasibility of steroid-free regimens, at the expense of a slight increase in the rate of acute rejection, which is an important end point in any clinical trial of relatively short duration. The largest epidemiological study to date has reassured the transplant community that the selective use of steroid-free immunosuppression in kidney transplant patients provides no inferior outcome in patient and graft survival at intermediate term. Steroid-free regimens have the potential to improve cardiovascular risk profile. The challenges that remain are to identify the subset of kidney transplant patients who may not benefit from steroid-free immunosuppression and to demonstrate the survival advantage of steroid-free immunosuppresion in suitable kidney transplant candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.