ReviewThe American journal of clinical nutrition2009
Variation in umami perception and in candidate genes for the umami receptor in mice and humans.
Review in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Effects of purine and pyrimidine 5'-ribonucleotides on glutamate detection threshold and umami intensity in Japanese young female trained participants.Chemical senses · 2025Article
- Ribonucleotides differentially modulate oral glutamate detection thresholds.Chemical senses · 2024Article
- Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?Diabetes & metabolism journal · 2020Review
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Kokumi Taste Active Peptides Modulate Salt and Umami Taste.Nutrients · 2020Article
- A Brief Review of Genetic Approaches to the Study of Food Preferences: Current Knowledge and Future Directions.Nutrients · 2019Review
- Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.FEBS open bio · 2017Article
- The interactions between different tastes on initiation of reflex swallow elicited by electrical stimulation in humans.Odontology · 2016Article
- Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.BMC genomics · 2016Article
- Minireview: Nutrient sensing by G protein-coupled receptors.Molecular endocrinology (Baltimore, Md.) · 2013Review
- The gustatory and olfactory systems during infancy: implications for development of feeding behaviors in the high-risk neonate.Clinics in perinatology · 2011Review
- Cooking clue to human dietary diversity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genetics of taste and smell: poisons and pleasures.Progress in molecular biology and translational science · 2010Review
- Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.The American journal of clinical nutrition · 2009Article
- Taste receptors for umami: the case for multiple receptors.The American journal of clinical nutrition · 2009Article
- Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.The American journal of clinical nutrition · 2009Article
- Luminal chemosensing and upper gastrointestinal mucosal defenses.The American journal of clinical nutrition · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unique taste induced by monosodium glutamate is referred to as umami taste. The umami taste is also elicited by the purine nucleotides inosine 5'-monophosphate and guanosine 5'-monophosphate. There is evidence that a heterodimeric G protein-coupled receptor, which consists of the T1R1 (taste receptor type 1, member 1, Tas1r1) and the T1R3 (taste receptor type 1, member 3, Tas1r3) proteins, functions as an umami taste receptor for rodents and humans. Splice variants of metabotropic glutamate receptors, mGluR(1) (glutamate receptor, metabotropic 1, Grm1) and mGluR(4) (glutamate receptor, metabotropic 4, Grm4), also have been proposed as taste receptors for glutamate. The taste sensitivity to umami substances varies in inbred mouse strains and in individual humans. However, little is known about the relation of umami taste sensitivity to variations in candidate umami receptor genes in rodents or in humans. In this article, we summarize current knowledge of the diversity of umami perception in mice and humans. Furthermore, we combine previously published data and new information from the single nucleotide polymorphism databases regarding variation in the mouse and human candidate umami receptor genes: mouse Tas1r1 (TAS1R1 for human), mouse Tas1r3 (TAS1R3 for human), mouse Grm1 (GRM1 for human), and mouse Grm4 (GRM4 for human). Finally, we discuss prospective associations between variation of these genes and umami taste perception in both species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.