ArticleJournal of clinical microbiology2009
Census and analysis of persistent false-negative results in serological diagnosis of human immunodeficiency virus type 1 group O infections.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- HIV rapid screening tests and self-tests: Be aware of differences in performance and cautious of vendors.EBioMedicine · 2018Trial
- HIV-1 Non-Group M Strains and ART.Viruses · 2023Review
- Evaluation of HIV-1 rapid diagnostic tests in the context of viral genetic diversity in Libreville (Gabon).The Pan African medical journal · 2022Article
- Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations.BMC infectious diseases · 2021Article
- Phylogeny of partialHeliyon · 2020Article
- An automated clinical mass spectrometric method for identification and quantification of variant and wild-type amyloid-β 1-40 and 1-42 peptides in CSF.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- A cheap and open HIV viral load technique applicable in routine analysis in a resource limited setting with a wide HIV genetic diversity.Virology journal · 2017Article
- Multiple HIV-1/M + HIV-1/O dual infections and new HIV-1/MO inter-group recombinant forms detected in Cameroon.Retrovirology · 2017Article
- Evaluation of Hologic Aptima HIV-1 Quant Dx Assay on the Panther System on HIV Subtypes.Journal of clinical microbiology · 2016Article
- Novel Time-Resolved Fluorescence Europium Nanoparticle Immunoassay for Detection of Human Immunodeficiency Virus-1 Group O Viruses Using Microplate and Microchip Platforms.AIDS research and human retroviruses · 2016Article
- A Multiplex PCR Approach for Detecting Dual Infections and Recombinants Involving Major HIV Variants.Journal of clinical microbiology · 2016Article
- Performance of the Liaison XL Murex HIV Ab/Ag test on clinical samples representing current epidemic HIV variants.Journal of clinical microbiology · 2014Article
- Clinical evaluation of BioPlex 2200 HIV Ag-Ab, an automated screening method providing discrete detection of HIV-1 p24 antigen, HIV-1 antibody, and HIV-2 antibody.Journal of clinical microbiology · 2014Article
- Non-M variants of human immunodeficiency virus type 1.Clinical microbiology reviews · 2013Review
- A new real-time quantitative PCR for diagnosis and monitoring of HIV-1 group O infection.Journal of clinical microbiology · 2012Article
- Baseline genotypic and phenotypic susceptibilities of HIV-1 group O to enfuvirtide.Antimicrobial agents and chemotherapy · 2010Article
- Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas.Journal of virology · 2010Article
- Performance of the BioPlex 2200 HIV Ag-Ab assay for identifying acute HIV infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical VirologyArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency viruses (HIV) have a high level of genetic diversity. The outlier variants of HIV type 1 (HIV-1) group O are distantly related to HIV-1 group M. Their divergence has an impact on serological diagnosis, with a risk of false-negative results. In this study, we report 20 failure cases, involving patients with primary or chronic infection, in France and Cameroon between 2001 and 2008. Our results indicate that some assays detected group O infection much less efficiently than others. Two major reasons for these false-negative results were identified: the presence or absence of a group O-specific antigen (and the designed sequence) for the detection of antibodies and the greater envelope variability of group O than of group M strains. This study highlights the complexity of screening for these divergent variants and the need to evaluate test performance with a large panel of strains, due to the extensive diversity of group O variants.
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