ArticleSexually transmitted infections2009
Rapid progression of an anal Buschke-Lowenstein tumour into a metastasising squamous cell carcinoma in an HIV-infected patient.
Article in Sexually transmitted infections, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Case Report: Definitive radiotherapy for inoperable anal Buschke-Löwenstein tumors: two cases with literature review.Frontiers in oncology · 2026Article
- Radiation Therapy in the Management of Extensive Giant Condyloma Acuminata With Rectal Involvement: A Case Report.Cureus · 2024Article
- [Anogenital warts-An update].Dermatologie (Heidelberg, Germany) · 2024Review
- The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview.International journal of molecular sciences · 2022Review
- Malign Differentiation of a Large Buschke Loewenstein Tumor in Penis.Surgery journal (New York, N.Y.) · 2018Article
- [Buschke-Lowenstein tumors].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017Review
- Successful improvement of Buschke-Löwenstein tumour in an HIV-infected patient with antiretroviral therapy alone.BMJ case reports · 2016Article
- Intra-abdominal localisation of a buschke-lowenstein tumour: case presentation and review of the literature.Case reports in transplantation · 2013Article
- Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ.Techniques in coloproctology · 2011Article
- The role of dermatopathology in conjunction with teledermatology in resource-limited settings: lessons from the African Teledermatology Project.International journal of dermatology · 2011Article
- [HPV infections of the oral and genital mucosa. Possibilities for primary prevention].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBuschke-Löwenstein tumour (BLT) of the anogenitalia is a locally invasive, destructively growing verrucous carcinoma that does not metastasise. Histologically BLT resembles benign condylomata acuminata. Nevertheless, the tumour grows relentlessly and may rarely progress into squamous cell cancer (SCC).
resultsA human immunodeficiency virus (HIV)-infected immunosuppressed patient developed (peri)anal warts accompanied by recurrent abscesses and fistulae. Histology revealed condylomata acuminata, and low-risk genital human papillomavirus (HPV) type 11b was detected. Six months later, the tumour had progressed into an ulcerated SCC that destroyed the rectum and perineum, with metastases to the inguinal lymph nodes. Whereas highly active antiretroviral therapy (HAART) effectively suppressed HIV replication, radiochemotherapy plus anti-EGFR antibody did not halt tumour progression, and the patient died from tumour-cachexia. DISCUSSION: As far as is known, this is the first report demonstrating rapid progression of a BLT into a metastasising SCC in an HIV-infected patient.
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