ArticleBMC medical genetics2009
Functional analysis of the C-reactive protein (CRP) gene -717A>G polymorphism associated with coronary heart disease.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Association of - 717 A > G (rs2794521) CRP polymorphism with high cardiovascular risk by C-reactive protein in systemic lupus erythematosus patients.Clinical rheumatology · 2023Article
- Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections.Frontiers in immunology · 2021Review
- Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea.Molecular genetics & genomic medicine · 2019Article
- No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation.Frontiers in pharmacology · 2019Article
- Correlation between genetic polymorphisms within the MAPK1/HIF-1/HO-1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease.Clinical cardiology · 2017Article
- Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study.International journal of environmental research and public health · 2016Article
- Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study.Balkan medical journal · 2015Article
- A novel haplotype within C-reactive protein gene influences CRP levels and coronary heart disease risk in Northwest Indians.Molecular biology reports · 2014Article
- Genetic and environmental influences on the prospective correlation between systemic inflammation and coronary heart disease death in male twins.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Association study of CRP gene and ischemic stroke in a Chinese Han population.Journal of molecular neuroscience : MN · 2013Article
- Relationship between CRP polymorphism and cardiovascular events in Chinese peritoneal dialysis patients.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- Study of C-reactive protein and myocardial infarction in the Indian population.Indian journal of clinical biochemistry : IJCB · 2012Article
- CRP gene variation affects early development of Alzheimer's disease-related plaques.Journal of neuroinflammation · 2011Article
- Should C-reactive protein be a target of therapy?Diabetes care · 2011 · on this mapReview
- Linking variants from genome-wide association analysis to function via transcriptional network analysis.Seminars in nephrology · 2010Review
- Inflammation-induced atherosclerosis as a target for prevention of cardiovascular diseases from early life.The open cardiovascular medicine journal · 2010Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtherosclerosis underlies the major pathophysiological mechanisms of coronary heart disease (CHD), and inflammation contributes to all phases of atherosclerosis. C-reactive protein (CRP), a sensitive, but nonspecific marker of inflammation has been shown to play proatherogenic roles in the process of atherosclerosis. Our previous report showed that rs2794521 (-717A>G), located in the promoter of the CRP gene, was independently associated with CHD in Chinese subjects. In the present study, we tried to investigate the biological significance of this genetic variation in vitro.
methodsThe influence of G to A substitution at the site of rs2794521 on the transcriptional activity of the promoter of the CRP gene was assessed by luciferase reporter assay, and protein binding to the site of rs2794521 was detected by EMSA assay.
resultsThe G to A exchange at the site of rs2794521 resulted in an increased transcriptional activity of the promoter of CRP gene, and glucocorticoid receptor (GR) protein factor bound drastically differently to the A and G alleles at the site of rs2794521.
conclusionThese results provided functional evidence supporting the association of the SNP rs2794521 of the CRP gene with CHD probably through regulating the expression level of CRP by different variations of rs2794521.
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