ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2009
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients.Transplantation · 2017Article
- Novel Therapeutics Identification for Fibrosis in Renal Allograft Using Integrative Informatics Approach.Scientific reports · 2017Article
- T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2014Article
- Transplantation tolerance and its outcome during infections and inflammation.Immunological reviews · 2014Review
- Induction of tolerance through mixed chimerism.Cold Spring Harbor perspectives in medicine · 2014Review
- Regulatory B cells and tolerance in transplantation: from animal models to human.Frontiers in immunology · 2013Review
- Transplantation: Autoantibodies-epiphenomena or biological clues.Nature reviews. Nephrology · 2013Article
- Moving beyond HLA: a review of nHLA antibodies in organ transplantation.Human immunology · 2013Review
- Biologic agents in islet transplantation.Current diabetes reports · 2013Review
- The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism.European journal of immunology · 2013Article
- Composite tissue allotransplantation and dysregulation in tissue repair and regeneration: a role for mesenchymal stem cells.Frontiers in immunology · 2013Article
- Experimental models of B cell tolerance in transplantation.Seminars in immunology · 2012Review
- Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.Kidney international · 2011Article
- Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation.Transplantation · 2011Article
- Biomarkers of tolerance: searching for the hidden phenotype.Kidney international supplements · 2011Article
- Tolerance in clinical transplantation: progress, challenge or just a dream?Langenbeck's archives of surgery · 2011Review
- Hematopoietic chimerism and transplantation tolerance: a role for regulatory T cells.Frontiers in immunology · 2011Article
- Article
- Emerging role of B cells in chronic allograft dysfunction.Kidney international. Supplement · 2010Review
- The significance of non-T-cell pathways in graft rejection: implications for transplant tolerance.Transplantation · 2010Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Five patients with end-stage kidney disease received combined kidney and bone marrow transplants from HLA haploidentical donors following nonmyeloablative conditioning to induce renal allograft tolerance. Immunosuppressive therapy was successfully discontinued in four patients with subsequent follow-up of 3 to more than 6 years. This allograft acceptance was accompanied by specific T-cell unresponsiveness to donor antigens. However, two of these four patients showed evidence of de novo antibodies reactive to donor antigens between 1 and 2 years posttransplant. These humoral responses were characterized by the presence of donor HLA-specific antibodies in the serum with or without the deposition of the complement molecule C4d in the graft. Immunofluorescence staining, ELISA assays and antibody profiling using protein microarrays demonstrated the co-development of auto- and alloantibodies in these two patients. These responses were preceded by elevated serum BAFF levels and coincided with B-cell reconstitution as revealed by a high frequency of transitional B cells in the periphery. To date, these B cell responses have not been associated with evidence of humoral rejection and their clinical significance is still unclear. Overall, our findings showed the development of B-cell allo- and autoimmunity in patients with T-cell tolerance to the donor graft.
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Registered trials
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