Evidence map›Paper›PMID 19624276›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009

Macronutrient supplementation for malnourished HIV-infected adults: a review of the evidence in resource-adequate and resource-constrained settings.

John R Koethe, Benjamin H Chi, Karen M Megazzini, Douglas C Heimburger, Jeffrey S A Stringer

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Increased risk of aminoglycoside-induced hearing loss in MDR-TB patients with HIV coinfection.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Low BMI and falling BMI predict HIV-associated tuberculosis: a prospective study in Tanzania.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2010
    Trial
  17. Supplementary feeding in the care of the wasted HIV infected patient.Malawi medical journal : the journal of Medical Association of Malawi · 2010
    Trial
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

John R KoetheCentre for Infectious Disease Research in Zambia, Lusaka, Zambia. john.r.koethe@vanderbilt.edu
Benjamin H Chi
Karen M Megazzini
Douglas C Heimburger
Jeffrey S A Stringer
Centre for Infectious Disease Research in Zambia · ZMPediatric Nephrology of Alabama · USUniversity of Alabama at Birmingham · USWestat (United States) · US

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
A Training Program in International Women's HealthK01TW006670 · FIC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHI, BENJAMIN H. · 2005 to 2009
$512k
METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIAR21AI076430 · NIAID · VANDERBILT UNIVERSITY · PI HEIMBURGER, DOUGLAS CORBETT · 2008 to 2010
$324k
FIC NIH HHS K01 TW006670FIC NIH HHS K01-TW06670FIC NIH HHS R24 TW007988FIC NIH HHS R24-TW007988NIAID NIH HHS R21 AI076430
6 · The paper itself

Abstract

Access to antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection has expanded rapidly throughout sub-Saharan Africa, but malnutrition and food insecurity have emerged as major barriers to the success of ART programs. Protein-calorie malnutrition (a common form of malnutrition in the region) hastens HIV disease progression, and food insecurity is a barrier to medication adherence. Analyses of patient outcomes have identified a low body mass index after the start of ART as an independent predictor of early mortality, but the causes of a low body mass index are multifactorial (eg, normal anthropometric variation, chronic inadequate food intake, and/or wasting associated with HIV infection and other infectious diseases). Although there is much information on population-level humanitarian food assistance, few data exist to measure the effectiveness of macronutrient supplementation or to identify individuals most likely to benefit. In this report, we review the current evidence supporting macronutrient supplementation for HIV-infected adults, we report on clinical trials in resource-adequate and resource-constrained settings, and we highlight priority areas for future research.

Indexed as

Developed CountriesDeveloping CountriesDietary SupplementsFood, FormulatedFood SupplyAdultClinical Trials as TopicDisease ProgressionHealth ResourcesHIV InfectionsHIV Wasting SyndromeHumansPoverty AreasProtein-Energy Malnutrition

Identifiers

PMID19624276
PMCPMC3092426
OpenAlexW2113734714

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.