ArticleThe Journal of chemical physics2009
Enhancement of charged macromolecule capture by nanopores in a salt gradient.
Article in The Journal of chemical physics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Addressing the Challenges of Solid-State Nanopores: Strategies for Performance Enhancement.International journal of molecular sciences · 2026Review
- Optimizing the sensitivity and resolution of hyaluronan analysis with solid-state nanopores.Scientific reports · 2022Article
- Molecular rheotaxis directs DNA migration and concentration against a pressure-driven flow.Nature communications · 2017Article
- Influence of concentration polarization on DNA translocation through a nanopore.Physical review. E · 2016Article
- Biomedical diagnosis perspective of epigenetic detections using alpha-hemolysin nanopore.AIMS materials science · 2015Article
- Multiscale Multiphysics and Multidomain Models I: Basic Theory.Journal of theoretical & computational chemistry · 2013Article
- Variational multiscale models for charge transport.SIAM review. Society for Industrial and Applied Mathematics · 2012Article
- Theory of capture rate in polymer translocation.The Journal of chemical physics · 2010Article
- Article
- Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient.Nature nanotechnology · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Nanopores spanning synthetic membranes have been used as key components in proof-of-principle nanofluidic applications, particularly those involving manipulation of biomolecules or sequencing of DNA. The only practical way of manipulating charged macromolecules near nanopores is through a voltage difference applied across the nanopore-spanning membrane. However, recent experiments have shown that salt concentration gradients applied across nanopores can also dramatically enhance charged particle capture from a low concentration reservoir of charged molecules at one end of the nanopore. This puzzling effect has hitherto eluded a physically consistent theoretical explanation. Here, we propose an electrokinetic mechanism of this enhanced capture that relies on the electrostatic potential near the pore mouth. For long pores with diameter much greater than the local screening length, we obtain accurate analytic expressions showing how salt gradients control the local conductivity which can lead to increased local electrostatic potentials and charged analyte capture rates. We also find that the attractive electrostatic potential may be balanced by an outward, repulsive electro-osmotic flow that can in certain cases conspire with the salt gradient to further enhance the analyte capture rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.