Evidence map›Paper›PMID 19623876›Full record

ReviewActa clinica Croatica2009

New concepts of neural regulation in human nasal mucosa.

James N Baraniuk, Samantha J Merck

Abstract readReview
In one paragraph

Review in Acta clinica Croatica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. G-Protein-Coupled Receptor Signaling in Cilia.Cold Spring Harbor perspectives in biology · 2017
    Review
  6. Article
  7. Management of Smell Dysfunction.Current allergy and asthma reports · 2012
    Article
  8. Subjective nasal fullness and objective congestion.Proceedings of the American Thoracic Society · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

James N BaraniukDivision of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC 20007-2197, USA. baraniuj@georgetown.edu
Samantha J Merck
Georgetown University · US

Funding

Sensory/Medical CoreP50DC006760 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI BEAUCHAMP, GARY K · 2004 to 2009
$8.6M
WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9M
Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeR01ES015382 · NIEHS · GEORGETOWN UNIVERSITY · PI BARANIUK, JAMES N · 2006 to 2009
$1.5M
NCRR NIH HHS M01 RR023942NIDCD NIH HHS P50 DC006760NIEHS NIH HHS 1 R01 ES015382NIEHS NIH HHS R01 ES015382
6 · The paper itself

Abstract

Nasal mucosa is innervated by multiple subsets of nociceptive, parasympathetic and sympathetic nerves. These play carefully coordinated roles in regulating glandular, vascular and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent recognition of distinct classes of nociceptive nerves with unique patterns of sensory receptors that include seven transmembrane G-protein coupled receptors, new families of transient receptor potential and voltage and calcium gated ion channels, and combinations of neurotransmitters that can be modulated during inflammation by neurotrophic factors has revolutionized our understanding of the complexity and subtlety of nasal innervation. These findings may provide a rational basis for responses to air temperature changes, culinary and botanical odorants ("aromatherapy"), and inhaled irritants in conditions as diverse as idiopathic nonallergic rhinitis, occupational rhinitis, hyposmia, and multiple chemical sensitivity.

Indexed as

HumansNasal MucosaSensory Receptor CellsSmellSodium ChannelsTRPV Cation ChannelsSodium ChannelsTRPV Cation Channels

Identifiers

PMID19623876
PMCPMC4209304
OpenAlexW1624398869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.