ArticleDeutsches Arzteblatt international2008
Metastases in the Absence of a Primary Tumor: Advances in the Diagnosis and Treatment of CUP Syndrome.
Article in Deutsches Arzteblatt international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Risk factors for cancer of unknown primary: a literature review.BMC cancer · 2023Pooled it
- Non-Small Cell Lung Carcinoma Presenting as Isolated Malignant Ascites in the Absence of a Detectable Primary Tumor: A Case Report and Literature Review.Clinical case reports · 2026Article
- Beyond the Bowel: Lung Cancer Presenting as Complicated Diverticulitis.Journal of community hospital internal medicine perspectives · 2025Article
- Cancer Diaspora of Undifferentiated Cancer.Cureus · 2024Article
- Nanotechnology-aided advancement in the combating of cancer metastasis.Cancer metastasis reviews · 2022Review
- KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion.Nature communications · 2021Article
- The impact of the patient's condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients.Cancer management and research · 2019Article
- Does Cancer of Unknown Primary (CUP) Truly Exist as a Distinct Cancer Entity?Frontiers in oncology · 2019Review
- CUP Syndrome-Metastatic Malignancy with Unknown Primary Tumor.Deutsches Arzteblatt international · 2018Review
- Molecular driver alterations and their clinical relevance in cancer of unknown primary site.Oncotarget · 2016Article
- Patients with cancer of unknown primary: a retrospective analysis of 223 patients with adenocarcinoma or undifferentiated carcinoma.Deutsches Arzteblatt international · 2014Article
- [Structured diagnostics and therapy of the CUP syndrome].Der Radiologe · 2014Article
- [Cancer of unknown primary. Epidemiology and pathogenesis].Der Radiologe · 2014Article
- The morphological and molecular diagnosis of lung cancer.Deutsches Arzteblatt international · 2011Review
- [The initial CUP situation and CUP syndrome: pathological diagnostics].Der Pathologe · 2009Review
- Correspondence (letter to the editor): Additional Points From the Perspective of Ear, Nose, and Throat Medicine.Deutsches Arzteblatt international · 2009Article
- Correspondence (letter to the editor): Cervical Lymph Node Metastases of Unknown Primaries.Deutsches Arzteblatt international · 2009Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe term cancer of unknown primary site (CUP) syndrome is used to describe malignancies in which a complete diagnostic work-up detects metastases in the absence of an identifiable primary tumor.
methodsBased on a selective literature review, national and international guidelines, and the experience of the "Arbeitskreis CUP-Syndrom der Arbeitsgemeinschaft Internistische Onkologie der Deutschen Krebsgesellschaft" (CUP Syndrome Committee of the Medical Oncology Joint Working Group of the German Cancer Society), developments in the diagnosis and treatment of CUP syndrome are reported.
resultsMost patients diagnosed with CUP have an unfavorable prognosis, with a life expectancy of less than 12 months. Nevertheless, it is important to identify subsets of patients in whom specific treatment offers the chance of long-term survival or even full recovery. DISCUSSION: Only rigorous further development of diagnostic tools and treatment protocols will enable an improvement of the poor prognosis of patients with CUP syndrome. Specific molecular treatment strategies have shown promising results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.