ArticleCurrent opinion in otolaryngology & head and neck surgery2009
Regulation of cell fate and patterning in the developing mammalian cochlea.
Article in Current opinion in otolaryngology & head and neck surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Single-Cell Profiling of the Developing Organ of Corti Identifies Etv4/5/1 as Key Regulators of Pillar Cell Identity.bioRxiv : the preprint server for biology · 2026Article
- Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea.Cells · 2025Article
- Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation.Science advances · 2021Article
- Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens.Scientific reports · 2020Article
- Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.Cold Spring Harbor perspectives in medicine · 2020Review
- Didelphis albiventris: an overview of unprecedented transcriptome sequencing of the white-eared opossum.BMC genomics · 2019Article
- GSK3 regulates hair cell fate in the developing mammalian cochlea.Developmental biology · 2019Article
- Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.eLife · 2016Article
- Where hearing starts: the development of the mammalian cochlea.Journal of anatomy · 2016Review
- Sensational placodes: neurogenesis in the otic and olfactory systems.Developmental biology · 2014Review
- PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice.Neuroreport · 2014Article
- Article
- A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea.Development (Cambridge, England) · 2012Article
- Evidence for a partial epithelial-mesenchymal transition in postnatal stages of rat auditory organ morphogenesis.Histochemistry and cell biology · 2012Article
- Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.PLoS biology · 2012Article
- Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.PloS one · 2012Article
- Scleraxis is required for differentiation of the stapedius and tensor tympani tendons of the middle ear.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research.Hearing research · 2011Review
- Dissecting the molecular basis of organ of Corti development: Where are we now?Hearing research · 2011Review
- Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Hearing research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewA significant proportion of hearing loss and deafness is caused by defects in the structure or function of cells within the organ of Corti. Identification of the molecular factors that regulate the development of this structure should provide valuable insights regarding inner ear formation and the signaling pathways that underlie congenital auditory deficits. In addition, targeted modulation of these same factors could be developed as therapies for hair cell regeneration. RECENT
findingsResults from experiments using transgenic and mutant mice, as well as in-vitro techniques, have identified genes and signaling pathways that are required to either specify unique auditory cell types, such as hair cells or supporting cells, or to generate the highly ordered cellular pattern that is characteristic for the organ of Corti. In particular, the hedgehog and fibroblast growth factor signaling pathways modulate the formation of the progenitor cells that will give rise to the organ of Corti. SRY-box containing gene 2, a transcription factor that is required for the formation of the cochlear progenitor cell population, has paradoxically been shown to also act as an inhibitor of hair cell development. Finally, the motor protein myosin II regulates extension of the organ of Corti and the alignment of hair cells and supporting cells into ordered rows. SUMMARY: A better understanding of the signaling pathways that direct different aspects of cochlear development, such as specific of cell fates or cellular patterning, offers the potential to identify new pathways or molecules that could be targeted for therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.