ArticleHuman heredity2009
A new method to account for missing data in case-parent triad studies.
Article in Human heredity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Bayesian Zero- Inflated Poisson model for prognosis of demographic factors associated with using crystal meth in Tehran population.Medical journal of the Islamic Republic of Iran · 2018Article
- Statistical count models for prognosis the risk factors of hepatitis C.Gastroenterology and hepatology from bed to bench · 2013Article
- Specific count model for investing the related factors of cost of GERD and functional dyspepsia.Gastroenterology and hepatology from bed to bench · 2013Article
- Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study.International journal of molecular epidemiology and genetics · 2012Article
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Authors and funding
2 authors.
Funding
Abstract
BACKGROUND/
aimsThe case-parent triad design is commonly used in genetic association studies. Generally, samples are drawn from an affected offspring, manifesting a phenotype of interest, as well as from the parents. The trio genotypes may be analyzed using a variety of available methods, but we focus on log-linear models because they test for genetic association and additionally estimate the relative risks of transmission. The models need to be modified to adjust for missing genotypes. Furthermore, instability in the parameter estimates can arise when certain kinds of genotype combinations do not appear in the dataset.
methodsIn this paper, we kill two birds with one stone. We propose a new method to simultaneously account for missing genotype data and genotype combinations with zero counts. This method solves a zero-inflated Poisson (ZIP) regression likelihood. The maximum likelihood estimates yield relative risks and the information matrix gives appropriate variance estimates for inference. A likelihood ratio test determines the significance of genetic association.
resultsWe compared the ZIP regression to previously proposed methods in both simulation studies and in a dataset that investigates the risk of orofacial clefts. The ZIP likelihood estimates regression coefficients with less bias than other methods when the minor allele frequency is small.
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